Week 4 - AKI and Urinary Tract Seminar Flashcards
what is AKI characterized by
- abrupt decline in kidney function
- elevated serum creatinine and/or reduction in urine output
is AKI reversible?
- often it is
describe the mortality for AKI
- high
what are the 3 main categories of AKI
- pre renal
- intrarenal
- post renal
what is pre renal AKI
- decreased profusion to the kidney (marked decrease in renal blood flow)
- decreased glomerular filtration rate
what is an intrarenal AKI
- direct damage to the renal tissue
what is a postrenal AKI
- mechanical obstruction of urinary outflow
what are the 5 major roles of the kidneys
- filter & excrete metabolic wastes
- regulate blood vol & pressure
- produce erythropoietin
- regulate electrolytes
- regulate pH
what should we ask about for health history for AKI
- history of current symptoms
- PMHx
- PSHx
- family Hx
- meds
- social Hx (smoking, drugs)
- occupation Hx
- dietary/fluid intake
how long does it take for pre and post renal injuries to resolve if they have not caused intrarenal damage?
- usually promptly with correction of cause
list 6 meds/drug that may be harmful to the kidney (6)
- NSAIDs
- aminoglycosides
- ACE inhibitors at high doses
- cocaine
- heroin
- chemo –> methotrexate
what is ATN?
- acute tubular necrosis
- the most common intrarenal cause of AKI
what are the 3 phases of ATN? what is the timeline for each?
- initiation (24 hrs to a week)
- maintenance (10-14 days to months)
- recovery (up to a year)
what is the initiation phase of ATN characterized by
- increase in serum creatinine
- drop in urine output
what is the most common manifestation of the maintenance phase of ATN
- ologuria (<400 mL/24h)
what other symptoms are seen during the maintenance phase of ATN (9)
- urinary changes (oliguria)
- fluid retentions: HTN, edema
- metabolic acidosis
- sodium normal or low
- hyperkalemia
- anemia, platelet defects, WBC altered
- calcium deficit, phosphate excess
- azotemia (increased BUN and creatinine)
- neurological disorders
(very similar to CKD)
even tho sodium is normal or below-normal, why should excessive intake of sodium be avoided during ATN
- can lead to volume expansion, HTN, and CHF
what are characteristics of the recovery phase of ATN (6)
- return of BUN, creatinine, and GFR towards normal
- may experience diuretic phase & increased urine output
- hypovolemia & hypotension
- dehydration
- hyponatremia
- hypokalemia
why do people experience a diuretic phase during the recovery phase of ATN
- bc the kidney’s have recovered their ability to excrete wastes but not concentrate the urine
describe physical assessment for ATN in the initiation phase (3)
- vital signs (BP, HR) for signs of fluid retention
- ins and outs (sign of drop in u/o)
- lab work: BUN and creatinine
describe physical assessment for ATN during the recovery phase
monitor:
- ins and outs
- signs of hypokalemia
- signs of hyponatremia
- signs of hypovolemia/dehydration
what are signs of hyponatremia
Stupor
Abdominal cramping
Lethargy
Trouble concentrating (confused)
Loss of urine & appetite
Orthostatic hypotension, overactive bowel sounds
Shallow respirations
Seziures, spasm of muscles
what are signs of hypokalemia
Lethargy Low, shallow resp Lethal cardiac dysrhythmias Lots of urine Leg cramps Limp muscles Low BP and HR
what are some signs of dehydration/hypovolemia (5)
- tenting
- dry mucus membranes
- low BP
- sunken eyes
- dry, cool skin
what is glomerulonephritis
- immune related inflammation of the glomeruli
what is glomerulonephritis characterized by (4)
- proteinuria
- hematuria
- decreased urine production
- edema (periorbital common)
what is important for assessment of glomerulonephritis
- history! especially:
1. recent viral or bacterial infections
2. autoimmune conditions
3. immunization history
what is glomerulonephritis often associated with
- recent (1-3 weeks ago) history of strept A infection
= post-strep glomerulonephritis
list symptoms of post-strep glomerulonephritis
- some are symptomactic (urinalysis)
- hematuria
- HTN
- oliguria
- periorbital/peripheral edema
- abdominal or flank pain
what is a sign of hematuria in post-strep glomerulonephritis
- coke/tea colored or smoky urine