Virulence Factors Definitions Flashcards
1
Q
- Cell wall – useful for bacterial viability, homeostasis, protect the bacteria
from attack by host lysozyme
A
2
Q
- protein A - bind Fc of IgG protects, blocks immune response, & opsonization
A
3
Q
- binding or clamping factors – attachment to host proteins
A
4
Q
- Capsule (slime layer) – useful for
adhesion
prevents chemotaxis and
inhibit phagocytosis by polymorphonuclear leukocytes
A
- Adhesion
- Hide/cover the surface of the bacterial cell by depositing host sialic
acid residues on their surfaces - Thus, capsule prevents bacterial recognition by phagocytes, prevents
complement assisted opsonization (inhibit phagocytic killing)
5
Q
- hyaluronidase - breaks down connective tissue between adjacent cells
(digs deeper between cells)
A
6
Q
- catalase – protects against host reactive oxygen species (ROS) e.g. H2O2
A
7
Q
- coagulase - clots blood to hide in it
A
8
Q
- staphylokinase - lyses clots (fibrin) to come out of it and disperse itself
A
9
Q
- lipase - digest lipids, thus allows to colonize skin surface & sebaceous
glands
A
10
Q
- protease - destroys tissue proteins
A
11
Q
- beta-lactamases - inactivate beta-lactam drugs’ thus, survive treatment
A
12
Q
- hemolysin (alpha, beta, or gamma) - destroys red blood cells,
neutrophils, macrophages, platelets
A
13
Q
- cytolytic toxins (leukocidin)- destroy cell membranes of host cells
(leukocytes)
A
14
Q
- exfoliative toxin – separate skin layers, resulting in impetigo & skin
layer peel off
A
15
Q
- toxic shock syndrome (TSS) toxin – causes
a. shock &
b. superantigens (Mass T cell activation i.e. 20% of all body T cells)
A