uworld week of 7/27 Flashcards
Lynch syndrome cancers
colorectal
endometrial
ovarian
FAP cancers
colorectal
desmoids and osteomas
brain tumors
Von Hippel Lindau cancers
hemangioblatomas
clear rcc
pheo
MEN 1 cancers
Parathyroid
pituitary
pancreatic
when to start endometrial biopsy with Lynch?
when to hysterectomy?
30
40
RV failure signs
elevated jvp right ventricle 3rd heart sound tricuspid regurgitate murmur hepatomegaly with pulsatile liver edema and acsities pleural effusion
what dysfunction causes swelling in Cor pulmonate
pulmonary artery systolic pressure cause RV dysfunction
TX for asymptomatic PAC’s
nothing but stop drinking, smoking,and caffeine, give BB if symptomatic
Bacillary angiomatosis cause manifestation and tx
Bartonella henslae, cats or home less lice), vascular cutaneous lesions(papular, nodular, pedunculate)
organ involvement
fever, night sweats, fatigue
tx: doxy or erythromycin
Addisons labs
hyperK, hypoNa, eiosiophillia
high ACTH, low morning cortisol
patients with smoke inhalation injury imperically treated with_____ for ____
hydroxycoalbumin or sodiumthiosulfate to tx cyanide toxicity
why does cyanide cause met acidosis
reduces oxygen utilization by tissues by binding FE3+ stops ATP
why are multiple myeloma patients at increased risk for infection
impaired antibody production after bone marrow infiltrated
vitamin deficiency with long term metformin
B12
initial tx for hyperventilation syndrome
breathing retraining and reassurance
idiopathic transverse myelitis pathophys
immune destruction of spinal cord, often post infectious
idiopathic transverse myelitis clinical ft
bilat motor weakness, early flaccid (LMN), late spastic(UMN)
distinct sensory level
autonomic dysfunction
idiopathic transverse myelitis dx
MRI T2 hyper intensity
LP: ⬆️ WBC⬆️ IgG index
idiopathic transverse myelitis tx
high dose intravenous steroids
plasmapheresis
RA patient with nephrotic syndrome
amyloidosis, multiple myeloma also increases risk of amyloidosis
tx for sporotrichosis
3-6 months of itraconazole
migrane prophylaxis meds
BB
TCA
Topiramate
divalproex sodium
which thyroid cancer had increased calcitonin
medullary( the one in men 2 a and b
meds for essential tremor
non selective BB like propranalol
anti seizure like primidone
polyarthritis rheumatica tx
prednisone, watch for this in older people with elevated ESR and no other inflammatory markers
what cancer do people with pernicious anemia get
gastric
what are patients with nephrotic syndrome at an increased risk for
atherosclerosis due to hyperlipidemia and av thrombus due to loss of anti thrombin 3.
older person holding things far away to read dx
presbyopia, caused by loss of lens elasticity
what is telogen effluvium
acute diffuse nonimflamatory hair loss. triggered by illness of stress, treat by addressing underlying cause
treatment escalation ankylosing spondylitis
NSAIDS/Cox-2
TNF alpha inhibitors like etanercept and infliximab
anti IL 17 like secukinbumab
sacrocid electrolyte abnormality sometimes
hyper ca
amioderone side effects
Brady/❤️ block QT prolongation --> torsades chronic interstitial pneumonitis hyper or hypothyroid hepatitis corneal micro deposits and optic neuropathy bluegray skin peripheral neuropathy
tx for uric acid stone prevention
potassium citrate to alkalize urine
how does sodium bicarb help TCA overdose
Sodium load will stop action on myocardial sodium channels.
how does sodium bicarb help Aspirin overdose
urine alkalization increases excretion
what test to do before methotrexate
liver function for sure
long term cyclophosphamide is associated with
increased incidence of acute hemorrhagic cystitis and bladder carcinoma
first tx for cocaine induced chest pain
Benzos, do normal heart attack things except BB if they are having a heart attack
ATN casts
muddy brown
most common med that causes angioedema
ACE-i
what eye thing are storage weber kids at risk for
glaucoma
