Tumormarker Flashcards

1
Q

Alkalische Leukozytenphosphatase

A

Bei CML im Ggs. zu anderen myeloproliferativen Erkrankungen erniedrigt

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2
Q

S100

A

Verlaufskontrolle malignes Melanom

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3
Q

Calretinin, Vimentin

A

Mesotheliom

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4
Q

Zytokeratin 5/6

A

Mesotheliom, Plattenepithelkarzinom

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5
Q

TTF-1 (Tyroidaler Transkriptionsfaktor)

A

Adenokarzinom der Lunge, SD-Karzinome (papillär, follikulär, anaplastisch)

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6
Q

NSE (Neuronenspezifische Enolase)

A

SCLC, Neuroblastom, (weisen immunhistochemisch Zellen des disseminierten endokrinen Systems nach), neuroendokrine Tumore

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7
Q

SCC (Squamous-Cell-Ca-Antigen)

A

NSCLC

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8
Q

Pankreaskarzinom

A

CA 19-9 und CEA

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9
Q

Bronchialcarzinom

A

CEA

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10
Q

CCC

A

CA 19-9

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11
Q

Ovarialkarzinom

A

CA 15-3

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12
Q

Mammakarzinom

A

CA 15-3 (Verlaufskontrolle)

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13
Q

Magenkarzinom

A

CA 72-4 (CEA, CA 19-9)

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14
Q

CYFRA 21-1

A

NSCLC

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15
Q

5-HIAA im 24h Urin ↑, Serotonin und Chromogranin A im Serum ↑

A

Karzinoidsyndrom

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16
Q

CD-117

A

Tyrosinkinase-R (KIT) Mutation in GIST-Tumoren

17
Q

CA 19-9

A

Pankreaskarzinom, CCC, KRK, Magenkarzinom

18
Q

CA 125

A

Ovarialkarzinom (Verlauf), Adenokarzinom der Zervix, maligner Aszites

19
Q

ß-HCG

A

SS, Keimzelltumor und Chorionkarzinom, Hodenkarzinom (Seminom, ChorionCa, Embryonalem Ca)

20
Q

AFP

A

HCC, Keimzelltumore von Hoden und Ovar

21
Q

ProGRP

A

Hochspezifisch für SCLC

22
Q

Leu-M1-AK

A

Adenokarzinom Lunge

23
Q

Pleuramesotheliom

A

Zytokeratin und Calretinin

24
Q

Fibröses Mesotheliom

A

Vimentin!!!, Zytokeratin, calretinin

25
Q

CEA

A

Adenokarzinome: Bronchial, Mamma, KRK, Pankreas, Magen, Medulläres SDC!!, EndometriumCA

26
Q

AFP

A

HCC, Keimzelltumore (Dottersacktumor)

27
Q

SP (saure phosphatase)

A

Prostatakarzinom

28
Q

Nebennierenrindenkarzinom (Immunhistochemische Marker)

A

Vimentin, Chromogranin A, Zytokeratin

29
Q

CA 72-4

A

Muzinöses Zystadenokarzinom (Ovar), Magenkarzinom

30
Q

Tumormarker Urologie

A

PSA: Prostata-Ca
ß-HCG: Seminom und Nichtseminom
AFP: Nur Nichtseminom!!!!
LDH: Seminom und Nichtseminom

31
Q

EndometriumCA

A

CEA, CA125, CA72-4

32
Q

OvarialCA

A

CEA, CA125, CA15-3

33
Q

Inhibin

A

Granulosazelltumor

34
Q

PLAP

A

Seminom, plazentäre AP, kein Standard, kann bei nicht ß-HCG sezernierenen Tumoren postiv sein. Falsch positiv bei Rauchern

35
Q

Synaptophysin

A

Neuroendokrine Tumore

36
Q

Desmin

A

Rhabdo/Leiomyosarkom, Mesotheliom

37
Q

Mesothelin

A

(Membranständiges Glykoprotein) Pankreas, Ösophagus, MagenCA, Mesotheliom