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IMMUNE 1 LEC > TUMOR IMMUNOLOGY > Flashcards

TUMOR IMMUNOLOGY Flashcards

1
Q

Estrogen/progesterone receptors

A

Cell surface markers

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2
Q

Estrogen/progesterone receptors

A

Cell surface markers

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3
Q

Thyroglobulin (TG)

A

Proteins

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4
Q

Immunoglobulins (Ig) and Ig light chains

A

Proteins

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5
Q

Alpha-1-fetoprotein (AFP)

A

Oncofetal antigens

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6
Q

Carcinoembryonic antigen (CEA)

A

Oncofetal antigens

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7
Q

CA 125

A

Carbohydrate antigens

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8
Q

CA 15-3

A

Carbohydrate antigens

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9
Q

CA 19-9 (related to Lewis antigens)

A

Blood group antigens

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10
Q

Prostate-specific antigen (PSA)

A

Enzymes/isoenzym es

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11
Q

Alkaline phosphatase (ALKP)

A

Enzymes/isoenzym es

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12
Q

Neuron specific enolase

A

Enzymes/isoenzym es

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13
Q

Human chorionic gonadotropin (hCG)

A

Hormones

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14
Q

Calcitonin

A

Hormones

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15
Q

Gastrin

A

Hormones

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16
Q

Prognosis for hormone therapy in breast cancer

A

Estrogen/progesterone receptors

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17
Q

Clonality and lineage of white blood cell neoplasms

A

CD markers on white blood cells

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18
Q

Well differentiated papillary or follicular thyroid carcinoma

A

Thyroglobulin (TG)

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19
Q

Multiple myeloma and lymphoid malignancies

A

Immunoglobulins (Ig) and Ig light chains

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20
Q

Germ cell carcinoma, hepatocellular carcinoma

A

Alpha-1-fetoprotein (AFP)

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21
Q

Colorectal carcinoma and some others

A

Carcinoembryonic antigen (CEA)

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22
Q

Ovarian cancer

A

CA 125

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23
Q

Breast Cancer

A

CA 15-3

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24
Q

Pancreatic and gastrointestin al cancers

A

CA 19-9 (related to Lewis antigens)

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25
Q

Prostate cancer

A

Prostate-specific antigen (PSA)

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26
Q

Bone and liver cancer

A

Alkaline phosphatase (ALKP)

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27
Q

Neural tissue neoplasms

A

Neuron specific enolase

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28
Q

Germ cell carcinoma, trophoblastic tumors

A

Human chorionic gonadotropin (hCG)

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29
Q

Medullary thyroid cancer

A

Calcitonin

30
Q

Pancreatic gastrinoma

A

Gastrin

31
Q

Prostate; Digital rectal exam; Men over 50 and with at least 10 years of life expectancy

A

Prostate-specific antigen (PSA, total and free)

32
Q

Colorectal; Genetic testing; Subjects over 50 years old for occult blood; genetic testing in high-risk subjects

A

Fecal occult blood

33
Q

Liver; Ultrasound; High-risk subjects

A

Alpha-1-fetoprotein (AFP)

34
Q

Ovarian; Ultrasound; Subjects with family history of ovarian cancer

A

Carbohydrate antigen 125 (CA 125)

35
Q

Nonseminomatous; Germ cell cancer ; Liver cancer

A

AFP (alpha-1- fetoprotein)

36
Q

1, 2, 3, 4

Fetal liver and yolk sac, adult liver

A

AFP (alpha-1- fetoprotein)

37
Q

Pregnancy, non neoplastic liver disease

A

AFP (alpha-1- fetoprotein)

38
Q

Screening for high-risk populations for liver cancer as those with liver cirrhosis and chronic hepatitis

A

AFP (alpha-1- fetoprotein)

39
Q

2

MHC class I

A

Β-2 microglobulin

40
Q

Inflammatory high cell turnover conditions

A

Β-2 microglobulin

41
Q

Higher levels imply poor prognosis in multiple myeloma

A

Β-2 microglobulin

42
Q

Familial medullary thyroid carcinoma

A

Calcitonin and Ca++ (serum calcium)

43
Q

N/A

Thyroid

A

Calcitonin and Ca++ (serum calcium)

44
Q

In hypercalcemia, increased calcitonin is expected.

A

Calcitonin and Ca++ (serum calcium)

45
Q

Can be elevated in other forms of cancer

A

Calcitonin and Ca++ (serum calcium)

46
Q

Serum Ca++ may be low when calcitonin is in medullary carcinoma

A

Calcitonin and Ca++ (serum calcium)

47
Q

White blood cell (WBC)

A

CD markers (cluster of differentiation in WBC)

48
Q

N/A

All WBCs

A

CD markers (cluster of differentiation in WBC)

49
Q

WBC increase such as infection

A

CD markers (cluster of differentiation in WBC)

50
Q

An array of CD markers are associated with WBC malignancies

A

CD markers (cluster of differentiation in WBC)

51
Q

Colorectal; Breast

A

CEA (Carcinoembryonic antigen)

52
Q

2, 3, 4

Tissues of entodermal origin

A

CEA (Carcinoembryonic antigen)

53
Q

Renal failure, non neoplastic liver and intestinal disease, age

A

CEA (Carcinoembryonic antigen)

54
Q

Values increased with age and in smokers

A

CEA (Carcinoembryonic antigen)

55
Q

Ovarian adenocarcinoma

A

CA125 (CA = carbohydrate antigen)

56
Q

1, 2, 3, 4

Various

A

CA125 (CA = carbohydrate antigen)

57
Q

Endometriosis, pelvic inflammatory disease, uterine fibroids, and pregnancy

A

CA125 (CA = carbohydrate antigen)

58
Q

Don’t collect specimen during menstruation (false increase

A

CA125 (CA = carbohydrate antigen)

59
Q

Breast ; Can be increased in pancreatic, lung, colorectal, ovarian, and liver cancers

A

CA15-3

60
Q

4

Mammary tissue

A

CA15-3

61
Q

Benign liver disease; Benign breast disease

A

CA15-3

62
Q

Epitope of episialin. 15-3 is monoclonal antibody.; Others are 27.29 and 549 4

A

CA15-3

63
Q

Pancreatic

A

CA 19-9

64
Q

1, 2, 4

Sialyated Lewis a blood group antigen

A

CA 19-9

65
Q

Benign hepatobiliary and pancreatic conditions

A

CA 19-9

66
Q

Can be elevated in some nonpancreatic malignancies.

A

CA 19-9

67
Q

Subjects who are Lewis a and b negative cannot synthesize CA 19-9

A

CA 19-9

68
Q

Breast 2

A

ER/PR (Estrogen/progesterone receptors)

69
Q

Breast N/A

A

ER/PR (Estrogen/progesterone receptors)

70
Q

breast cancers and adenocarcinoma benefit from estrogen/ progesterone reduction therapy.

A

ER/PR (Estrogen/progesterone receptors)

IMMUNE 1 LEC (28 decks)

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