KEY TERMS

Question 1

P-450 enzymes

Answer 1

Addison’s disease

Question 2

p-ANCA, pancreatic acinar cells

Answer 2

Crohn’s disease

Question 3

P-450 enzymes

Answer 3

Ovarian failure/infertility

Question 4

Parietal cells

Answer 4

Pernicious anemia

Question 5

p-ANCA

Answer 5

Ulcerative colitis

Question 6

Reduce inflammation by inhibiting macrophage cytokine secretion

Answer 6

Corticosteroids

Question 7

Blocks T cell cytokine production by inhibiting the phosphatase calcineurin and then blocking activation of the NFAT transcription factor

Answer 7

Cyclosporine and FK506

Question 8

Blocks lymphocyte proliferation by inhibiting guanine nucleotide synthesis in lymphocytes

Answer 8

Mycophenolate mofetil

Question 9

Blocks lymphocyte proliferation by inhibiting IL-2 signaling

Answer 9

Rapamycin

Question 10

Depletes T cells by binding to CD3 and promoting phagocytosis or complement-mediated lysis (used to treat acute rejection)

Answer 10

Anti-CD3 monoclonal antibody

Question 11

Inhibits T cell proliferation by blocking IL-2 binding; may also opsonize and help eliminate activated IL-2R-expressing T cells

Answer 11

Anti-IL-2 receptor antibody

Question 12

Inhibits T cell activation by blocking B7 costimulator binding to T cell CD28 (clinical trials)

Answer 12

CTLA4-1g

Question 13

A selective T cell costimulation blocker

Answer 13

Nulojix (belatacept)