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IMMUNE 1 LEC > CHAPTER 6.2 - STAGES OF B AND T CELL DIFFERENTIATION > Flashcards

CHAPTER 6.2 - STAGES OF B AND T CELL DIFFERENTIATION Flashcards

1
Q

Derived from a multipotential progenitor cell particularly, the lymphoid-myeloid progenitor

A

PRO-B CELL

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2
Q

IL-7 is necessary

A

PRO-B CELL

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3
Q

CD 24, CD19 and CD45R are the present surface markers

A

PRO-B CELL

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4
Q

Rearrangement of genes on chromosome 14 coding for the heavy chain

A

PRO-B CELL

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5
Q

When synthesis of the heavy chain part of the antibody molecule occurs, it begins

A

PRE-B CELL

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6
Q

Mu chains in cytoplasm (IgM) are prominent

A

PRE-B CELL

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7
Q

first heavy chains synthesized

A

IgM

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8
Q

Rearrangement of genes coding for light chains
o Kappa = chromosome 2
o Lambda = chromosome 22

A

PRE-B CELL

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9
Q

1st expressed Ab on the surface: IgM

A

IMMATURE B CELL

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10
Q

Monomer

A

IgM

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11
Q

This indicates that rearrangement of the genetic sequence coding for light chains on either chromosome 2 or 22 has taken place by this time. Completion of light chain rearrangement commits a cell to produce an antibody molecule with specificity for a particular antigen or group of related antigens.

A

IMMATURE B CELL

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12
Q

CD21 (Epstein-Barr virus) and CD 35

A

IMMATURE B CELL

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13
Q

2nd on the surface: IgD

A

MATURE B CELL

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14
Q

Released in the bone marrow

A

MATURE B CELL

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15
Q

Naïve B cell – encountered not Ag

A

MATURE B CELL

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16
Q

When activated by an Ag. CD25 appears which is a receptor for lI-2 to enhance proliferation of lymphocytes

A

ACTIVATED T CELL

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17
Q

Result of Ag stimulation and transformation of activated B cells

A

PLASMA CELLS

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18
Q

B cell surface markers disappears

A

PLASMA CELLS

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19
Q

Abundant cytoplasmic Ig which are excreted in the blood stream as ANTIBODIES/ IMMUNOGLOBULINS

A

PLASMA CELLS

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20
Q

Early thymocytes lack CD4 and CD8 markers

A
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21
Q

– T helper T cells

A

o CD4

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22
Q

– Cytotoxic T cells

A

o CD8

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23
Q

Large thymocytes actively proliferate in the outer cortex under the influence of interleukin-7.

A

DOUBLE NEGATIVE STAGE

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24
Q

Rearrangement of the genes that code for the antigen receptor known as TCR begins at this stage

A

DOUBLE NEGATIVE STAGE

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25
Q

The combination of beta chain with CD3 forms the pre-TCR receptor.

A

DOUBLE NEGATIVE STAGE

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26
Q

Signaling by the Beta chain also triggers the thymocyte to become CD4 positive and CD8 positive.

A

DOUBLE NEGATIVE STAGE

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27
Q

– the complex that will serve as the main part of the T cell antigen receptor (TCR)

A

CD3

28
Q

thymocytes express both CD4 and CD8 antigens

A

DOUBLE POSITIVE STAGE

29
Q

rearrangement of the genes coding for the alpha chain

A

DOUBLE POSITIVE STAGE

30
Q

CD3-αβ receptor complex (TCR) is expressed

A

DOUBLE POSITIVE STAGE

31
Q

process takes place that allows only doublepositive cells with functional TCR receptors to survive

A
32
Q

T cells must recognize foreign anti gen in association with class I or class II MHC molecules

A
33
Q

class I –

A

CD8

34
Q

class II –

A

CD4

35
Q

Any thymocytes that are unable to recognize selfMHC antigens die without leaving the thymus.

A

Positive selection

36
Q

process, whereby the surviving cells recognize MHC determinants along with foreign antigen.

A

Negative selection

37
Q

The T cells are responsible for cell-mediated immunity, which involves production of cytokines that serve as regulatory factors for the immune response.

A

Negative selection

38
Q

Have single –positive expression of the surface markers

A
39
Q

MATURE T CELL TYPES

A
40
Q
  1. CD4+ / T-helper cells
A
41
Q

Activation of Tc and delayed hypersensitivity

A

Th1

42
Q

Produce: interferon gamma (IFN-γ) and tumor necrosis factor-beta (TNFβ)

A

Th1

43
Q

Activation of B cell

A

Th2

44
Q

Produce: IL-4, IL-5

A

Th2

45
Q

: used for IL-2 receptor in ACTIVATED T CELL

A

CD25

46
Q

: Promotes further proliferation of lymphocytes in ACTIVATED T CELL

A

IL-2

47
Q

Secretes lymphokines

A

SENSITIZED T CELL

48
Q

Produced by T lymphocyte

A

lymphokines

49
Q

maturation stages of B cells

A

B CELL DIFFERENTIATION

50
Q

– bone marrow derived lymphocytes

A

B lymphocytes

51
Q

precursor cell in antibody production

A

B lymphocytes

52
Q

T CELL DIFFERENTIATION

(?)of circulating lymphocytes in the peripheral blood are (?), and these become differentiated in the thymus.

A

60 to 80 percent

T cells

53
Q

T CELL DIFFERENTIATION

is also needed and critical for growth and differentiation

A

Interleukin 7

54
Q

Lymphocyte precursors called (?) enter the thymus from the bone marrow.

A

thymocytes

55
Q

T CELL DIFFERENTIATION

A significant selection process occurs as maturation takes place, because it is estimated that approximately (?) of the cortical cells die intrathymically before becoming mature T cells.

A

97 percent

56
Q

Much more strict compared to B cell differentiation

A

T CELL DIFFERENTIATION

57
Q

Similar to Pro-B cell with the need of IL-7

A

DOUBLE NEGATIVE STAGE

58
Q

important when interacting with an antigen

A

Positive selection

59
Q

takes place among the surviving double-positive T cells with functional TCR

A

Negative selection

60
Q

Strong reactions with self-peptides send a signal to delete the developing T cell by means of apoptosis, or programmed cell death.

A

Negative selection

61
Q

Most T cells that would be capable of an autoimmune response are eliminated

A

Negative selection

62
Q

This selection process is very rigorous

A

Negative selection

63
Q

Thymus checks if the double positive thymocytes are capable of reacting to self-molecules (came w/ BM function)

A

Negative selection

64
Q

Only (?) of the doublepositive thymocytes in the cortex survive

A

1-3 %

65
Q

– released from the thymus → peripheral blood or SLO

A

CD4 and CD4

66
Q

has encountered Ag; another surface marker (CD25) will be visible

A

ACTIVATED T CELL

IMMUNE 1 LEC (28 decks)

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