SUMMARY OF HEPATITIS Flashcards
Serum hepatitis
HBV
Post transfusion hepatitis
HCV
Non A and Non B hepatitis
HCV
Picornaviridae ssRNA
HAV
Hepadnaviridae dsDNA
HBV
Flaviviridae ssRNA
HCV
Deta virus; requires HBV for replication
HDV
Caliciviridae ssRNA
HEV
15-45 days
HAV
45-160 days
HBV
15-150 days
HCV
30-60 days
HDV
15-60 days
HEV
Fecal-oral
HAV
HEV
Sex, blood transfusion, sharing of needles, transplacental saliva, breastmilk
HBV
HDV
Sex, blood transfusion, sharing of needles, transplacental saliva, breastmilk, hemodialysis
HCV
Infectious hepatitis
HAV
• Present in stool and plasma for an average of 18 days after the clinical of disease
HAV RNA
• Indicates recent infection
Anti-HAV IgM
• Develops 2-3 weeks after ingestion and persists up to 3-6 mos
Anti-HAV IgM
• Develops 1-2 weeks after IgM
Anti-HAV IgG
• Present for life
Anti-HAV IgG
• Active hepatitis B
HbsAg
• Acute infection and infectivity
HbsAg
• General marker of infection
HbsAg
• Active hepatitis B with high degree with increased risk of infectivity
HBeAg
• Circulating for HbcAg
HBeAg
• Current or recent and hepatocellular acute hepatitis B
Anti-HBc IgM
• Important in diagnosing during window period.
Anti-HBc IgM
• Current or past hepatitis B
Total anti-HBc
• Recovery from hepatitis B
Anti-HBe
• Immunity to hepatitis B or past infection
Anti-HBs
• Acute, atypical, or occult hepatitis B
HBV DNA
• Viral load may be used to monitor effectiveness of therapy
HBV DNA
• Generally used to diagnose Hepatitis C infection.
Anti-HCV
• 4 weeks after infection (not reliable)
Anti-HCV
• Used in monitoring he response to antiviral therapy
HCV-RNA
• Diagnosis in the acute phase
HCV-RNA
• Identification of HCV genotype
HCV-RNA
increase risk infectivity
Indicated that virus has high degree of infectivity
Envelope antigen
Progression to chronic state
HBV
HCV
HDV
No Progression to chronic state
HAV
HEV
Acute, self limiting
HAV
HEV
Most: acute
HBV
Others: Chronic (10%-90%), cirrhosis, risk of Ca
HBV
80-85% will have a chronic disease
HCV
15-20% spontaneous resolution
HCV
Super infection/ coninfection with Hepatitis B
HDV
Acute selflimiting
HAV
HEV
Fluminant liver failure in pregnant women
HEV
(+) Early infection
Anti-HBc IgM
Total Anti-HBc
HBeAg
HBV DNA
(-) Early infection
Anti-HBs
Anti-HBe
(+) Window
Anti-HBc IgM
Total Anti-HBc
HBV DNA
(-) Window
HBeAg
HBsAg
Anti-HBs
Anti-HBe
(-) Convalescent
(+) Convalescent
(+/-) Convalescent
(-/+) Convalescent
(+/-) Chronic
(-/+) Chronic
(+) Chronic
(-) Chronic
(-) Post vaccination
(+) Post vaccination