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IMMUNE 1 LEC > BACTERIAL INFECTIONS - SEROLOGICAL TESTS FOR RICKETTSIA > Flashcards

BACTERIAL INFECTIONS - SEROLOGICAL TESTS FOR RICKETTSIA Flashcards

1
Q

Epidemic typhus, Brill Zinsser dse

A

R. prowazekii

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2
Q

Murine typhus

A

R. typhi

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3
Q

Scrub typhus

A

R. tsusugamushi

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4
Q

Rocky-Mountain Spotted Fever

A

R. rickettssi

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5
Q

Rickettsial pox

A

R. akari

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6
Q

Trench fever

A

Rartonella (Rochalimaea) quintana

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7
Q

Q fever

A

Coxiella burnetti

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8
Q

Weil-Frlix Test Principle:

A

Direct Agglutination

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9
Q

Differential Diagnosis

A
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10
Q

Based on cross-reactivity of the heterophile antibodies (patient) produced in response of rickettsial infection with the Ag in the 3 strains of Proteus

A

Weil-Frlix Test

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11
Q

o Proteus vulgaris:

A

OX-19 and OX-2

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12
Q

o Proteus mirabilis:

A

OX-K strain

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13
Q

: Abs that can also react w/ an Ag of a similar spp

A

heterophile antibodies

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14
Q

also considered as febrile disease

A

RICKETTSIA

SALMONELLA

BRUCELLA

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15
Q

R. prowazekii

OX-19
OX-2
OX-K

A

4+

+

0

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16
Q

R. typhi

OX-19
OX-2
OX-K

A

4+

+

0

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17
Q

R. tsutsugamushi

OX-19
OX-2
OX-K

A

0

0

4+

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18
Q

R. ricketsiii

OX-19
OX-2
OX-K

A

4+

4+

-

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19
Q

TYPHOID FEVER
Causative agent:

A

Salmonella typhi

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20
Q

TYPHOID FEVER
MOT:

A

Oral-fecal route (food, drinks, or stool)

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21
Q

TYPHOID FEVER
Carriers:

A

asymptomatic like typhoid mary/ bloody mary

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22
Q
  • cook in the US who got typhoid epidemic.

Worked for 7 families and infected 22 people, 3 of them died

A

Mary

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23
Q

Asymptomatic: carriers are infected prior; when they recovered, some of the bacteria went to the gallbladder to remain dormant

A

TYPHOID FEVER

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24
Q

SALMONELLA ANTIGENS THAT WILL PRODUCE THE FOLLOWING SALMONELLA ANTIGENS ARE:

A

 Salmonella enteritidis
 Salmonella typhi

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25
Q

Somatic antigen

A

O Antigen

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26
Q

Heat stable

A

O Antigen

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27
Q

Endotoxin

A

O Antigen

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28
Q

Polysaccharide

A

O Antigen

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29
Q

Flagellar Antigen

A

H Antigen

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30
Q

Protein

A

H Antigen

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31
Q

Heat labile

A

H Antigen

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32
Q

Capsular Antigen

A

Vi Antigen

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33
Q

Associated with virulent strains

A

Vi Antigen

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34
Q

Indicated carrier state

A

Vi Antigen

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35
Q

SEROLOGICAL TESTS FOR SALMONELLA
Gold Standard:

A

Bacterial culture

36
Q

SEROLOGICAL TESTS FOR SALMONELLA
Serologic tests:

A
  1. Widal
  2. Typhidot
  3. Tubex
37
Q

WIDAL
Principle:

Rgts used has been modified

A

Direct Agglutination Test

38
Q

Widal Antigen Suspension
o Antigen preparation:

A

 antigen + heat or alcohol (phenol)
 H antigen + formalin

39
Q

: heat-labile

40
Q

Principle:

detects serum antibody to antigen that is a dotted on a nitrocellulose membrane

41
Q

Aka Dot Enzyme Immunoassay

42
Q

Line in IgM:

A

Acute typhoid fever

43
Q

Line in IgG:

A

previously successfully treated
 Reinfection of Typhoid Fever
 Carrier status
 Recovery (most of the time)

44
Q

Both lines- transitioning from

A

acute to chronic or acute to recovery

45
Q

5-minute semiquantitative colorimetric test for typhoid fever

46
Q

One of the comparator tests aside from typhidot and and widal

47
Q

Detects anti-salmonella O9 bodies from a patient’s serum by the ability of these antibodies to inhibit the binding between an indicator antibody-bound particle and a magnetic antigen-bound to a particle

48
Q

Compare the intensity of the color

49
Q

10- positive result

50
Q

If the antibody is present- it will attract the antibody coated
indicator particle, thus intensifies the color

51
Q

Patient serum is placed on cuvettes
Darker color, more positive the patient sample is

52
Q

Causes brucellosis

53
Q

Zoonotic disease

54
Q

Gram (-) bacteria: pink

55
Q

MOT:
o Farm animals
o Consuming milk form farm animals

56
Q

Most reliable indicator

A

Agglutination method

57
Q

Test is performed on a filter paper with Brucella Ag

A

Surface fixation of the Castaneda strip test

58
Q

In the addition of the patient serum, if the patient’s antibody is present the serum will not flow

A

Surface fixation of the Castaneda strip test

59
Q

Use Castaneda medium

A

Surface fixation of the Castaneda strip test

60
Q

Extracellular bacteria
o hard to culture; use serologic

A

MYCOPLASMA PNEUMONIAE

61
Q

Causes PAP (Primary atypical pneumonia)/walking pneumonia

A

MYCOPLASMA PNEUMONIAE

62
Q

MYCOPLASMA PNEUMONIAE Mode of transmission:

A

Respiratory secretions

63
Q

MYCOPLASMA PNEUMONIAE Immunologic feature:

A

Cold agglutinins
• IgM antibodies (Auto anti-I)

64
Q

Develop individuals infected with the

A

M. pneumoniae

65
Q
  • not a serologic test but microbiolog ic assay
66
Q

Look for growth on specialized agars

67
Q

Difficult to grow and takes several weeks

68
Q

Antibodies crossreact with I antigen on group O red cells; look for agglutination

A

Cold agglutinin testing

69
Q

Easy to do but not specific for mycoplasma

A

Cold agglutinin testing

70
Q

Test for presence of IgG and IgM with purified antigens

71
Q

Sensitive and automated

72
Q

Antigen attached to slide and then reacted with antibody.

73
Q

An antiimmunoglobulin with a fluorescent tag is added

74
Q

Need to have a fluorescent microscope, and slide must be interpreted carefully

75
Q

Place biopsy material on urea agar. Color change as urea is broken down

A

Urease test

76
Q

Results in 2 hours. Invasive procedure, and organism may be missed due to uneven distribution in tissue

A

Urease test

77
Q

Patient ingests radioactive urea; bicarbonate produced, which is breathed out as CO2

A

Urea breath test

78
Q

Rapid and sensitive but involves radioactivity

A

Urea breath test

79
Q

To identify antigen in stool specimens

80
Q

Rapid but not as sensitive as urea breath test

81
Q

Used to determine success of therapy

82
Q

EIA test to determine presence of IgG or IgM

A

Antibody testing

83
Q

Best for initial screening method.

A

Antibody testing

84
Q

Not as reliable as antigen testing to evaluate therapy

A

Antibody testing

85
Q

Amplify specific DNA

86
Q

Rapid and sensitive but subject to contamination

IMMUNE 1 LEC (28 decks)

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