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IMMUNE 1 LEC > BACTERIAL INFECTIONS - SEROLOGICAL TESTS FOR RICKETTSIA > Flashcards

BACTERIAL INFECTIONS - SEROLOGICAL TESTS FOR RICKETTSIA Flashcards

1
Q

Epidemic typhus, Brill Zinsser dse

A

R. prowazekii

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2
Q

Murine typhus

A

R. typhi

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3
Q

Scrub typhus

A

R. tsusugamushi

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4
Q

Rocky-Mountain Spotted Fever

A

R. rickettssi

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5
Q

Rickettsial pox

A

R. akari

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6
Q

Trench fever

A

Rartonella (Rochalimaea) quintana

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7
Q

Q fever

A

Coxiella burnetti

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8
Q

Weil-Frlix Test Principle:

A

Direct Agglutination

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9
Q

Differential Diagnosis

A
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10
Q

Based on cross-reactivity of the heterophile antibodies (patient) produced in response of rickettsial infection with the Ag in the 3 strains of Proteus

A

Weil-Frlix Test

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11
Q

o Proteus vulgaris:

A

OX-19 and OX-2

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12
Q

o Proteus mirabilis:

A

OX-K strain

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13
Q

: Abs that can also react w/ an Ag of a similar spp

A

heterophile antibodies

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14
Q

also considered as febrile disease

A

RICKETTSIA

SALMONELLA

BRUCELLA

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15
Q

R. prowazekii

OX-19
OX-2
OX-K

A

4+

+

0

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16
Q

R. typhi

OX-19
OX-2
OX-K

A

4+

+

0

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17
Q

R. tsutsugamushi

OX-19
OX-2
OX-K

A

0

0

4+

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18
Q

R. ricketsiii

OX-19
OX-2
OX-K

A

4+

4+

-

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19
Q

TYPHOID FEVER
Causative agent:

A

Salmonella typhi

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20
Q

TYPHOID FEVER
MOT:

A

Oral-fecal route (food, drinks, or stool)

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21
Q

TYPHOID FEVER
Carriers:

A

asymptomatic like typhoid mary/ bloody mary

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22
Q
  • cook in the US who got typhoid epidemic.

Worked for 7 families and infected 22 people, 3 of them died

A

Mary

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23
Q

Asymptomatic: carriers are infected prior; when they recovered, some of the bacteria went to the gallbladder to remain dormant

A

TYPHOID FEVER

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24
Q

SALMONELLA ANTIGENS THAT WILL PRODUCE THE FOLLOWING SALMONELLA ANTIGENS ARE:

A

 Salmonella enteritidis
 Salmonella typhi

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25
Somatic antigen
O Antigen
26
Heat stable
O Antigen
27
Endotoxin
O Antigen
28
Polysaccharide
O Antigen
29
Flagellar Antigen
H Antigen
30
Protein
H Antigen
31
Heat labile
H Antigen
32
Capsular Antigen
Vi Antigen
33
Associated with virulent strains
Vi Antigen
34
Indicated carrier state
Vi Antigen
35
SEROLOGICAL TESTS FOR SALMONELLA Gold Standard:
Bacterial culture
36
SEROLOGICAL TESTS FOR SALMONELLA Serologic tests:
1. Widal 2. Typhidot 3. Tubex
37
WIDAL Principle: Rgts used has been modified
Direct Agglutination Test
38
Widal Antigen Suspension o Antigen preparation:
 antigen + heat or alcohol (phenol)  H antigen + formalin
39
: heat-labile
Formalin
40
Principle: detects serum antibody to antigen that is a dotted on a nitrocellulose membrane
TYPHIDOT
41
Aka Dot Enzyme Immunoassay
TYPHIDOT
42
Line in IgM:
Acute typhoid fever
43
Line in IgG:
previously successfully treated  Reinfection of Typhoid Fever  Carrier status  Recovery (most of the time)
44
Both lines- transitioning from
acute to chronic or acute to recovery
45
5-minute semiquantitative colorimetric test for typhoid fever
TUBEX
46
One of the comparator tests aside from typhidot and and widal
TUBEX
47
Detects anti-salmonella O9 bodies from a patient’s serum by the ability of these antibodies to inhibit the binding between an indicator antibody-bound particle and a magnetic antigen-bound to a particle
TUBEX
48
Compare the intensity of the color
TUBEX
49
10- positive result
TUBEX
50
If the antibody is present- it will attract the antibody coated indicator particle, thus intensifies the color
TUBEX
51
Patient serum is placed on cuvettes Darker color, more positive the patient sample is
TUBEX
52
Causes brucellosis
53
Zoonotic disease
BRUCELLA
54
Gram (-) bacteria: pink
BRUCELLA
55
MOT: o Farm animals o Consuming milk form farm animals
BRUCELLA
56
Most reliable indicator
Agglutination method
57
Test is performed on a filter paper with Brucella Ag
Surface fixation of the Castaneda strip test
58
In the addition of the patient serum, if the patient’s antibody is present the serum will not flow
Surface fixation of the Castaneda strip test
59
Use Castaneda medium
Surface fixation of the Castaneda strip test
60
Extracellular bacteria o hard to culture; use serologic
MYCOPLASMA PNEUMONIAE
61
Causes PAP (Primary atypical pneumonia)/walking pneumonia
MYCOPLASMA PNEUMONIAE
62
MYCOPLASMA PNEUMONIAE Mode of transmission:
Respiratory secretions
63
MYCOPLASMA PNEUMONIAE Immunologic feature:
Cold agglutinins • IgM antibodies (Auto anti-I)
64
Develop individuals infected with the
M. pneumoniae
65
- not a serologic test but microbiolog ic assay
Culture
66
Look for growth on specialized agars
Culture
67
Difficult to grow and takes several weeks
Culture
68
Antibodies crossreact with I antigen on group O red cells; look for agglutination
Cold agglutinin testing
69
Easy to do but not specific for mycoplasma
Cold agglutinin testing
70
Test for presence of IgG and IgM with purified antigens
EIA
71
Sensitive and automated
EIA
72
Antigen attached to slide and then reacted with antibody.
IFA
73
An antiimmunoglobulin with a fluorescent tag is added
IFA
74
Need to have a fluorescent microscope, and slide must be interpreted carefully
IFA
75
Place biopsy material on urea agar. Color change as urea is broken down
Urease test
76
Results in 2 hours. Invasive procedure, and organism may be missed due to uneven distribution in tissue
Urease test
77
Patient ingests radioactive urea; bicarbonate produced, which is breathed out as CO2
Urea breath test
78
Rapid and sensitive but involves radioactivity
Urea breath test
79
To identify antigen in stool specimens
Rapid EIA
80
Rapid but not as sensitive as urea breath test
Rapid EIA
81
Used to determine success of therapy
Rapid EIA
82
EIA test to determine presence of IgG or IgM
Antibody testing
83
Best for initial screening method.
Antibody testing
84
Not as reliable as antigen testing to evaluate therapy
Antibody testing
85
Amplify specific DNA
PCR
86
Rapid and sensitive but subject to contamination
PCR

IMMUNE 1 LEC (28 decks)

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