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IMMUNE 1 LEC > STAGES OF B AND T CELL DIFFERENTIATION > Flashcards

STAGES OF B AND T CELL DIFFERENTIATION Flashcards

1
Q

IL-7

A

Pro-B Cells

Double Negative Stage

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2
Q

IL-2

A

Activated B Cell

Activated T Cell

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3
Q

IgM

A

Pre-B Cell
Immature B Cell

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4
Q

IgM and IgD

A

Mature B Cell

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5
Q

Pro-B Cells Surface Marker

A

CD 24, CD19 and CD45R

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6
Q

Immature B Cell Surface Marker

A

CD21 (Epstein-Barr virus) and CD 35

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7
Q

Activated B Cell Surface Marker

A

CD25

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8
Q

Lacks CD4 and CD8

A

Double Negative Stage

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9
Q

Contains both CD4 and CD8 markers

A

Double Positive Stage

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10
Q

Either CD4 or CD8

A

Mature T Cells

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11
Q

Activated T Cell Surface Marker

A

CD25

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12
Q

Pro-B Cells

Rearrangement of the genes that codes for

A

heavy chain on:
chromosome 14

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13
Q

Pre-B Cell

Rearrangement of the genes that codes for

A

light chains
on:
o Kappa = chromosome 2
o Lambda = chromosome 22

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14
Q

Double Negative

Rearrangement of the genes that codes for

A

TCR (beta chain with CD3)

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15
Q

Double Positive

Rearrangement of the genes that codes for

A

TCR (alpha chain + beta chain with CD3 = CD3-αβ receptor complex)

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16
Q

Mu chains

A

Pre-B Cell

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17
Q

Naïve B cell

A

Mature B Cell

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18
Q

Antigen Independent Phase

A

Pro-B Cells

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19
Q

Important Growth or Transcription factors for differentiation

A

Pro-B Cells

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20
Q

Begins at the synthesis of the heavy chain part of antibody

A

Pre-B Cell

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21
Q

Immature B Cell Distinguishing characteristic:

A

Presence of complete IgM molecule in the cell surface

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22
Q

Immature B Cell 2 Destinations:

A

▪ Programmed cell death
▪ Cells leave the bone marrow and seed the lymphoid organs

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23
Q

Antigen-dependent phase

A

Mature B Cell

Activated B Cell

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24
Q

 Takes place in the spleen
o Marginal Zone B cell

A

Mature B Cell

25
 Lymph nodes and Other SLO o Follicular B Cell
Mature B Cell
26
Mature B Cell Distinguishing characteristic:
Presence of IgM and IgD- same specificity for a particular antigen or group of antigens
27
Primary Follicles of Peripheral Lymphoid tissues
Activated B Cell
28
Early thymocyte
Double Negative Stage
29
Double Negative Stage Active Proliferation
Outer cortex
30
Expression of CD3ab Receptor Complex
Double Postive Stage
31
Double positive cells with functioning TCR
Positive selection
32
Deletion of developing T cells
Negative Selection
33
Survivors of selection exhibit only one type of marker, either CD4 or CD8, and they migrate to the medulla.
Mature T Cells
34
✓ MHC Class II Protein
CD4+ T Cells
35
✓ MHC Class I Protein
CD8+ T Cells
36
✓ Cytotoxic T Cells
CD8+ T Cells
37
✓ Helper or Inducer T Cells
CD4+ T Cells
38
✓ TH1:
IFN-y and TNF-b
39
✓ TH2:
IL-4, IL-5, IL-10 and IL11
40
– site of differentiation
Thymus
41
– Lymphocyte Precursors
Thymocytes
42
– Chemical messenger that dictates migration of thymocyte
Chemokines
43
Early Surface markers of Thymocytes:
CD44 and CD25
44
Maturation period:
3 weeks
45
Characterized by polyribosome filled cytoplasm
46
Assisting B Cells in Antibody production
Activated T Cell
47
Kills tumor and other target cells
Activated T Cell
48
Rejects grafts
Activated T Cell
49
Stimulates hematopoiesis in the bone marrow
Activated T Cell
50
Stimulates delayed hypersensitivity reaction
Activated T Cell
51
Spherical or ellipsoidal
Plasma Cells
52
Characterized by: Abundant cytoplasmic Immunoglobulin
Plasma Cells
53
Nucleus: eccentric or oval (heavily clamped chromatinstains dark)
Plasma Cells
54
Abundant ER and well-defined golgi zone
Plasma Cells
55
Present in the germinal center of the peripheral lymphoid organ
Plasma Cells
56
Found in germinal layer
Memory Cells
57
Has longer life span
Memory Cells
58
Represents progeny of antigen stimulated B cells
Memory Cells
59
Similar in appearance with unstimulated B cells
Memory Cells

IMMUNE 1 LEC (28 decks)

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