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IMMUNE 1 LEC > STAGES OF B AND T CELL DIFFERENTIATION > Flashcards

STAGES OF B AND T CELL DIFFERENTIATION Flashcards

1
Q

IL-7

A

Pro-B Cells

Double Negative Stage

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2
Q

IL-2

A

Activated B Cell

Activated T Cell

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3
Q

IgM

A

Pre-B Cell
Immature B Cell

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4
Q

IgM and IgD

A

Mature B Cell

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5
Q

Pro-B Cells Surface Marker

A

CD 24, CD19 and CD45R

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6
Q

Immature B Cell Surface Marker

A

CD21 (Epstein-Barr virus) and CD 35

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7
Q

Activated B Cell Surface Marker

A

CD25

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8
Q

Lacks CD4 and CD8

A

Double Negative Stage

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9
Q

Contains both CD4 and CD8 markers

A

Double Positive Stage

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10
Q

Either CD4 or CD8

A

Mature T Cells

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11
Q

Activated T Cell Surface Marker

A

CD25

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12
Q

Pro-B Cells

Rearrangement of the genes that codes for

A

heavy chain on:
chromosome 14

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13
Q

Pre-B Cell

Rearrangement of the genes that codes for

A

light chains
on:
o Kappa = chromosome 2
o Lambda = chromosome 22

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14
Q

Double Negative

Rearrangement of the genes that codes for

A

TCR (beta chain with CD3)

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15
Q

Double Positive

Rearrangement of the genes that codes for

A

TCR (alpha chain + beta chain with CD3 = CD3-αβ receptor complex)

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16
Q

Mu chains

A

Pre-B Cell

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17
Q

Naïve B cell

A

Mature B Cell

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18
Q

Antigen Independent Phase

A

Pro-B Cells

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19
Q

Important Growth or Transcription factors for differentiation

A

Pro-B Cells

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20
Q

Begins at the synthesis of the heavy chain part of antibody

A

Pre-B Cell

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21
Q

Immature B Cell Distinguishing characteristic:

A

Presence of complete IgM molecule in the cell surface

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22
Q

Immature B Cell 2 Destinations:

A

▪ Programmed cell death
▪ Cells leave the bone marrow and seed the lymphoid organs

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23
Q

Antigen-dependent phase

A

Mature B Cell

Activated B Cell

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24
Q

 Takes place in the spleen
o Marginal Zone B cell

A

Mature B Cell

25
Q

 Lymph nodes and Other SLO
o Follicular B Cell

A

Mature B Cell

26
Q

Mature B Cell Distinguishing characteristic:

A

Presence of IgM and IgD- same specificity for a particular antigen or group of antigens

27
Q

Primary Follicles of Peripheral Lymphoid tissues

A

Activated B Cell

28
Q

Early thymocyte

A

Double Negative Stage

29
Q

Double Negative Stage Active Proliferation

A

Outer cortex

30
Q

Expression of CD3ab Receptor Complex

A

Double Postive Stage

31
Q

Double positive cells with functioning TCR

A

Positive selection

32
Q

Deletion of developing T cells

A

Negative Selection

33
Q

Survivors of selection exhibit only one type of marker, either CD4 or CD8, and they migrate to the medulla.

A

Mature T Cells

34
Q

✓ MHC Class II Protein

A

CD4+ T Cells

35
Q

✓ MHC Class I Protein

A

CD8+ T Cells

36
Q

✓ Cytotoxic T Cells

A

CD8+ T Cells

37
Q

✓ Helper or Inducer T Cells

A

CD4+ T Cells

38
Q

✓ TH1:

A

IFN-y and TNF-b

39
Q

✓ TH2:

A

IL-4, IL-5, IL-10 and IL11

40
Q

– site of differentiation

A

Thymus

41
Q

– Lymphocyte Precursors

A

Thymocytes

42
Q

– Chemical messenger that dictates migration of thymocyte

A

Chemokines

43
Q

Early Surface markers of Thymocytes:

A

CD44 and CD25

44
Q

Maturation period:

A

3 weeks

45
Q

Characterized by polyribosome filled cytoplasm

A
46
Q

Assisting B Cells in Antibody production

A

Activated T Cell

47
Q

Kills tumor and other target cells

A

Activated T Cell

48
Q

Rejects grafts

A

Activated T Cell

49
Q

Stimulates hematopoiesis in the bone marrow

A

Activated T Cell

50
Q

Stimulates delayed hypersensitivity reaction

A

Activated T Cell

51
Q

Spherical or ellipsoidal

A

Plasma Cells

52
Q

Characterized by: Abundant cytoplasmic Immunoglobulin

A

Plasma Cells

53
Q

Nucleus: eccentric or oval (heavily clamped chromatinstains dark)

A

Plasma Cells

54
Q

Abundant ER and well-defined golgi zone

A

Plasma Cells

55
Q

Present in the germinal center of the peripheral lymphoid organ

A

Plasma Cells

56
Q

Found in germinal layer

A

Memory Cells

57
Q

Has longer life span

A

Memory Cells

58
Q

Represents progeny of antigen stimulated B cells

A

Memory Cells

59
Q

Similar in appearance with unstimulated B cells

A

Memory Cells

IMMUNE 1 LEC (28 decks)

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