Tuberculosis Flashcards
1
Q
tuberculosis mechanism of action
A
mycobacterium grow slowly inside macrophages
pt may be asymptomatic
2
Q
tuberculosis tx challenges
A
adherence (may take up to 2 yrs to tx)
drug resistance (must take mult abx to combat)
toxicities - hepatotoxicity
cost
3
Q
tuberculosis meds
A
isoniazid
pyrazinamide
ethambutol
rifampin
4
Q
issues w/tuberculosis meds
A
requires mult abx for 2mo-6yrs
hepatotoxicity
numerous CYP interactions
5
Q
isoniazid
A
peripheral neuropathy
antidote: vitamin B6
6
Q
ethambutol
A
red-green color blindness
7
Q
rifampin
A
red-orange secretions
