Antiulcer

Question 1

peptic ulcer dz (PUD) increased risk

Answer 1

helicobacter pylori - main cause
meds (NSAIDS (ketorolac), corticoseroids, bisphosphates, chemo)
stress
smoking
tobacco
ETOH
acidic foods

Question 2

mechanism of proton pump inhibitors

Answer 2

inhibit function of proton pumps at gastric mucosal lining

Question 3

proton pump inhibitor meds

Answer 3

-prazoles
omeprazole
esomeprazole
pantoprazole
lansoprazole

Question 4

common uses of proton pump inhibitors

Answer 4

peptic ulcer dz
GERD
heartburn

Question 5

issues w/proton pump inhibitors

Answer 5

slow onset, short half-life
don’t crush/chew; take before breakfast
rebound sx: reflux, heartburn, gas
may cause: pneumonia, osteoporosis, hypomagnesemia

Question 6

H2 blocker meds

Answer 6

ranitidine
cimetidine
famotidine

Question 7

H2 blocker mechanism of action

Answer 7

block histamine in stomach to mildly aid problem (not as strong as proton pump inhibitors which block BOTH pumps)

Question 8

issues w/ H2 blockers

Answer 8

diminished effect over time
robound sx if abruptly stopped
confusion w/poor renal function

Question 9

sucralfate

Answer 9

coats stomach up to 6h

take before meals and 2h b/w other meds d/t absorption interference