Osteoporosis

Question 1

mechanism of osteroporosis

Answer 1

break down of bone cells by osteoclasts

Question 2

osteoporosis meds

Answer 2

bisphosphonates:
alendronate
ibandronate
risedronate

raloxifene

Question 3

issues w/bisphosphonates

Answer 3

heartburn, abdominal pain, diarrhea (GI issues!!)
hypocalcemia
osteonecrosis of the jaw

Question 4

raloxifene mechanism

Answer 4

mimics estrogen in bones; blocks estrogen in uterus and breasts
decreases cancer risk

Question 5

issues w/raloxifene

Answer 5

hot flashes
leg cramp
edema, weight gain
thromboembolism, stroke
decreased cancer risk