Antiemetics Flashcards

1
Q

mechanism of vomitting

A

NTs from stomach or inner ear trigger N/V

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2
Q

antiemetic meds

A

ondansetron
promethazine
metoclopramide

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3
Q

ondansetron

A

blocks 5HT3 (no effect on anxiety etc)
“clean drug”
headache, D/constipation, dizziness, prolonged QT interval–>torsades–>vFib
works better if administered prophylactically

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4
Q

promethazine

A

“dirty”
H1 block: sedation, dry mouth
D2 block: EPS
A1 block: orthostatic hypoTN

do NOT give to children<2yo
infiltration causes gangrene

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5
Q

metoclopramide

A

blocks D2, 5HT3 and promotes gastric motility
EPS, drowsiness
do NOT take >3months

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