Protein synthesis inhibitors Flashcards
1
Q
mechanism of protein synthesis inhibitors
A
bind to bacterial ribosomes to block protein synthesis
2
Q
protein synthesis inhibitor meds
A
tetracyclines:
tetracycline
macrolides:
erythromycin
azithromycin
aminoglycosides: gentamycin neomycin amikacin tobramycin streptomycin
3
Q
issues w/tetracyclines
A
esophageal ulcer - avoid taking hs
food interactions - milk, Ca2+, Mg, Fe, antacids
teeth discoloration <8yo d/t bind to Ca2+
photosensitivity
4
Q
issues w/macrolides
A
metallic taste
prolonged QT intervals
5
Q
issues w/aminoglycosides
A
nephrotoxic, ototoxic, inactivated by -cillins if mixed together upon administration
check labs
6
Q
peak
A
30min after IM or IV NTI drug level
7
Q
trough
A
NTI drug level right before next dose
