Dyslipidemia

Question 1

types of cholesterol

Answer 1

1. very low-density lipoprotein (worst)
2. low-density lipoprotein
3. high-density lipoprotein; 50/50 protein and fat

Question 2

dyslipidemia meds

Answer 2

-statins
cholesterol absorption inhibitors
bile-acid sequestrants
nicotinic acid "niacin"
fibrates

Question 3

-statins mechanism of action

Answer 3

halt formation of LDL and VLDL cholesterol via inhibition of an enzyme; causes slight increase in HDL

Question 4

statins to know

Answer 4

atorvastatin
lovastatin
rosuvastatin
simvastatin

Question 5

issues w/-statins

Answer 5

hepatotoxicity
myopathy (muscle problems)
rhapdomyolysis
avoid grapefruit

Question 6

rhapdomyolysis

Answer 6

myoglobin clogs kidneys to produce kidney failure
cola colored urine
check CK levels

Question 7

nicotinic acid “niacin”

Answer 7

vitamin B3 (meat)
increases HDL, decreases LDL
causes intense flushing of the face, GI issues
may take aspirin 30min prior to admin

Question 8

cholesterol absorption inhibitor

Answer 8

inhibits absorption of cholesterol from food during digestion
side effects: hepatitis, myopathy

Question 9

bile acid sequestrants

Answer 9

decrease LDL

many drug interactions

Question 10

fibrates

Answer 10

lowers VLDL, increases HDL

side effects: GI issues, gallstones, myopathy, hepatotoxicity