Transport of O2 and CO2

Question 1

Four types of hypoxia and examples

Answer 1

Histotoxic- cyanide toxicity
Hypoxic- COPD
Anemic-
Stagnant- low CO, PVD

Question 2

Normal HGB level

Answer 2

15g/dL

Question 3

How much of the o2 does hgb hold?

Answer 3

65x more than plasma

Question 4

HGB composition

Answer 4

2 a 2 b= 4 subunits
Normal adult- HbA=a2b2

Question 5

How much o2 can a gram of hgb hold?

Answer 5

1.34ml

Question 6

What is oxygen saturation?

Answer 6

Ratio of oxygen bound hgb compared to total amount that can be saturated

Question 7

Saturation and PaO2

Answer 7

100-100
95-75
90-60
70-40
50-27

Question 8

CO affinity to HGB

Answer 8

250x more than oxygen
Does not dissociate readily, takes hours to ride CO from body

Question 9

N2O

Answer 9

Binds hgb 200,000 more strongly than o2
Bind irreversably
For PH

Question 10

What increases hgb o2 affinity

Answer 10

HALDANE HOLDS O2
Hypothermia
Alkalosis
Low 2,3 DPG
blood transfusions
Carboxyhemoglobin/methemoglobin

Question 11

CaO2 formula

Answer 11

(1.34 x hgb x sao2) + (pao2 x .003)

Question 12

CO2 production /min

Answer 12

200ml/min
Exercise increases 6x

Question 13

Normal Co2 production and O2 consumption

Answer 13

CO2 production- 200ml/min
O2 consumption- 250ml/min

Question 14

AV difference for O2 and CO2

Answer 14

O2- 50ml/L (90-40)
CO2- 40ml/L (40 in vein 0 in artery)

Question 16

DO2 formula

Answer 16

cao2 x co x 10

Question 17

What decreases hgb affinity to o2

Answer 17

BHOR BYE O2
hyperthermia
acidosis
2,3 DPG