Renal 2 Don Flashcards
MALTS
Mannitol PCT
Acetazolamide PCT
Loop diuretics LOH
Thiazide diuretics DCT
Spironolactone CD
Normally, selective permeability permits approximately ___ of plasma elements to pass into the bowmans capsule, cells and proteins more than 60kDa ___
25%
Can not pass
The basement membrane is ____ charged due to ___ which composes it. ___ charged proteins are thus repelled and are unable to pass thru it.
Negatively
glycoproteins
Negatively
The two major determinants of filtration pressure are ___ and ___
glomerular capillary pressure (Pgc)
glomerular oncotic pressure (Pgc)
Normal GFR is ___, AKA ___ per day
120ml/ min
180L/ day
The vasa recta descends _____
Deep into the medulla, parallel to the LOH.
RBF is about ___ of CO
20%
2nd to only the liver
The vast majority of what is filtered is ___
reabsorbed
High hydrostatic pressure in the glomerular capillaries (60mmHg) causes ___
Rapid fluid filtration
Lower hydrostatic pressure in the peritubular capillaries (13mmHg) causes ___
rapid reabsorption
What are the factors that determine GFR?
1- ultrafiltration coefficient (cap permeability)
2- glomerular oncotic pressure (no protein, so direction should oppose filtration)
3- glomerular capillary pressure ( controlled by afferent and efferent arterioles)
4 capillary plasma flow rate
Formula for net filtration pressure-
Normal- 10mmHg
glomerular hydrostatic pressure- bowmans capsule pressure - glomerular oncotic pressure
What determines the glomerular hydrostatic pressure?
Arterial pressure- Increase MAP increases GFR, autoregulation
Afferent arteriolar resistance- Constriction reduces GFR, dilation increases GFR
Efferernt arteriolar resistance- constriction is biphasic- mild constriction increases GFR, excessive constriction reduces RBF and GFR, dilation reduces GFR
Most important factor of GFR
Glomerular hydrostatic pressure
(per apex, not even in dons top 4)
GFR is autoregulated between what pressures?
SBP 80-200
