Nuero

Question 1

Sodium channel blockers

Answer 1

Dont give meds within the same class

Question 2

What to do in first 5 mins of status epilepticus

Answer 2

1-ABC
2-BG (if <60, thiamine and D5W)
Adult: Thiamine 100 mg IV with 50 mL D5W
Child >= 2 yo: 2 ml/kg D25W IV
Child <2 yo: 4 ml/kg D12.5W IV
3-labs

Question 3

Carbamazepines SE

Answer 3

Drops sodium

Question 4

What to do 5-20 min after Status

Answer 4

Benzos
If unavailable- phenobarbital, diazepam, nasal versed

Question 5

20-40 min after status

Answer 5

Choose 1;
Fosphenytoin
Valproic acid
Levetiracetam

Question 6

40-60 minutes after status

Answer 6

Repeat any second line therapy
Anesthetic doses of thiopental, versed, pentobarbital, or propolfol

Question 7

MOAs of anti seizures

Answer 7

Na
CA (T)
Blockers
Carbonic anyhydrase inhibitors
Sex hormones
SV2A
GABA enhancers
Glutamate blockers

Question 8

Zonisamide SE

Answer 8

CNS excitatory- catch 22

Question 9

Best drugs in the class of NA blockers

Answer 9

Lacosamide
Cenobamate- also GABA modulator

Question 10

NA channel blockers

Answer 10

Carbamazepine (Tegretol, Carbatrol)
Oxcarbazepine (Trileptal)
Eslicarbazepine (Aptiom)
Phenytoin/Fosphenytoin (Dilantin)
Lamotrigine (Lamictal)
Zonisamide (Zonegran)
Lacosamide (Vimpat)
Cenobamate (Xcopri)

Question 11

Fosphenytoin/ phenytoin

Answer 11

Phenytoin- Same drug
Fos- Prodrug for phenytoin- PO safer, better tolerated, faster infusion rate

Question 12

Why not to stop benzo

Answer 12

Seizures/ withdrawal? listen to lecture

Question 13

Lamotrigine interacts with

Answer 13

Valproic acid

Question 14

Gabapentin use/ MOA

Answer 14

Seizure and neuropathy (mostly bc seize dose is too high)
GABA analogue

Question 15

Gabapentins + opioids

Answer 15

Respiratory depression

Question 16

Why is pregabalin diff than gabapentin

Answer 16

“Makes me feel drunk
Dizzy, drowsy, difficulty concentrating

Question 17

VPA MOA

Answer 17

Gaba modulator

Question 18

VPA SE

Answer 18

Interaction checkers bc its old
Teratogenic