BB final review Flashcards
CV changes in the elderly
Decreased elasticity in the arteries
Decreased HR
Decreased baroreceptor response
Increased afterload, systolic pressure
In the elderly, IV induction is ____, and ihnhaled induciton is ___
Slower
Faster
(Due to slower circulation time)
2 CV responses that are altered d/t bulnted B receptor response
Decreased max HR
Decreased peak EF
The EF of an alederly patient is more dependent on ___
LVEDV over HR
Makes them prone to CHF
Respiratory changes in the elderly
Decreased elasticity, alveolar surface area, cough, response to hypoxia and hypercarbia, RLC, DS,
Increased RV, CC, CV
VQ mismatch
GI changes in the elderly
PH rises
Gastric emptying slows
Smaller stomach
What is the most specific test for renal failure?
Cr Clearance to assess GFR
MAC for the elderly decreases __ per decade after age ___
4%
40
I thought 7?%?
How is albumin and AAG effected in the elderly?
Lower albumin
AAG increases- this binds LA and opioids
What is the functional unit of the liver?
Lobule
Acinus, zones of it
Relevant to hepatic fx
Zone 1- oxygen and nutrient gradients
Zone 3- highest concentration of cyp450
What are kupffer cells
Remove bacteria from blood before it enters the vena cava
Large bacterial load
The ___ is responsible for about half of lymph production in the body
Liver
Blood flow to the liver
Portal vein- 75% blood flow, 50% O2
Hepatic artery- 25% blood flow, 50% O2
Is the portal vein autoregulated?
No
Depends on SNS, pain, hypoxia, hypercarbia
Portal HTN S&S
Splenomegaly
Varicies of the esophagus
Stomach
Intestine
Normal portal vein pressure, and pressure needed for portal HTN diagnosis
7-10mmHg
>20mmHg
Hepatic artery flow formula
HAPP= MAP= HVP
Severe liver disease ____ the arterial buffer response to decreased blood flow
abolishes
Where does protein synthesis occur?
Liver
How are liver pts affected when given Succ?
Prolonged effects d/t decreased plasma cholinesterases
How do the elderly respons to NMBs?
No change in effects
Prolonged excretion
LFTs
Synthetic production- albumin, PT
Hepatocyte injury- AST, ALT
Biliary duct obstruction- 5-Nucelo
Hepatic clearance- Bilirubin
Anesthetic considerations for liver patients
Use iso or sevo, no des or halothane
No peep
Normocapnia
RA is ok if no coag defectrs
What drugs are hepatotoxic?
Acetaminophin
Halothane
Amio
ABX- PCN, tetracyclines, sulfa
Drug induced hepatitis can be caused from
Acetaminophen
Alcohol- most common drug
Halothane- immune mediated
Treatment of alcohol withdrawal
Alcohol
BBs
Alpha 2 agonists
Tx and S&SW for delerium tremens
Diazepam
BBs
Grand mal seizures, halucinations, nightmares, tachy, htn, n/v, confusion
S&S cholecystitis
Inflammation of gallbladder or cystic duct
Murphy sign- pain on inspiration
Fever, jaundice, RUQ pain
Surgical management of GERD
Nissen fundoplication