Kentucky Diabetes

Question 1

Oral antidiabetic classes

Answer 1

Secreatagogues/ sulfonylureas - glipizide, glyburide, blimepiride
Biguanides- metformin
Thiazolidinediones- pioglitazone
Alpha glucosidase inhibitors
GLP 1 agonists- ozempic

Question 2

Oral antidiabetic MOA

Answer 2

Secreatagogues/ sulfonylureas - stimulate beta cells to release more insulin
Biguanides- decrease glucose release and gluconeogenesis, no risk of hypoglycemia, decrease cholesterol
Thiazolidinediones- improve insulin sensitivity
Alpha glucosidase inhibitors- delay absorption of glucose
GLP 1 agonists- delayed gastric emptying, reduce glucagon secretion