Thermal, Itch, Pain sensation

Question 1

The magnitude of the afferent response for pain is dependent on what?

Answer 1

Frequency of action potentials

Question 2

What are ASICs?

Answer 2

Deg/ENaC

Acid sensing ion channels

Question 3

What are ASIC channels permeant to?

Answer 3

Na+

Question 4

How many TRP channels make 1 channel

Answer 4

4

Question 5

What ions are TRP channels permeant to?

Answer 5

Monovalent & divalent ions & calcium

Question 6

What is the main purpose of TRPs?

Answer 6

Thermoreceptor

Question 7

Can TRP channels be phosphorylated?

Answer 7

Yes

Calmodulase

Question 8

How are olfactory and TRP receptors similar?

Answer 8

Thermoreception of food mint, spice

Question 9

What are the itch mediators?

Answer 9

chemokines
Histamine
Kinins
5-HT

Question 10

What receptors initiate itch?

Answer 10

TRP

Question 11

TRP itch receptors are coupled with what protein? What type of receptor are itch TRP receptors?

Answer 11

Gq

Metabotropic

Question 12

During axonal injury, what channels are often inactivated and/or activated?

Answer 12

Nav1.8, 1.9 (downregulate)

Nav1.3 (upregulate)

Question 13

What causes neuropathic pain?

Answer 13

High frequency firing (accelerated de-inactivation) of injured axons & dorsal root ganglion

Question 14

Which fibers conduct first pain? Are they fast or slow?

Answer 14

Alpha-delta

Fast

Question 15

Which fibers conduct second pain? Are they fast or slow?

Answer 15

C

Slow

Question 16

What are the pain mediators for tissue damage?

Answer 16

P2X
5-HT3
ASIC
TRP

Question 17

What causes phantom/referred pain?

Answer 17

Pain crosses the mid-line and activates tracts associated with body segments