Glycogen breakdown Flashcards
WHat bond is between glucose molecules?
a 1,4 lgycosidic
What is the branching bond?
a 1,6 glycosidic
Benefits of glyocgen storage
Decreases osmotic load and amount of water needed
Advantages of glycogen
Muscle mobilizes glycogen faster than fat, fatty acid reisudes are not metabolized anaerobically, fatty acids are not glucogenic
What is McArdle’s disease?
GLycogen storing deficiancy
Starting point for glycogen synthase
Glycogenin - Glucose with Tyr-OH group
What is the rate limiting enzyme for glycogen synthesis?
Glycogen synthase. UDP-Glucose to Glycogen
What is the branching enzyme
1,4 -> 1,6 transglycosylase
Debranching enzyme
Glucosidase
GLycogen is stored as particles coupled with
enzymes that catalyze synthesis
enzymes that catalyz breakdown
UDP-Glucose is a branch point for what compounds?
Glycogen synthesis, Lactose synthesis, Uronic acid
What is Galactose’s intermediate compound for entry to glycolysis?
Galactose -> Glucose 1 Phosphate
What is Glycogen storage disease type IIIa?
Animals lack glycogen debranching enzyme
Short chain glycogens with a-1,4 links were observed
Is muscle glycogen synthesis affected by blood glucose levels?
No
