Ligand gated ion channels

Question 1

Where are ligand gated channels located in the nerve cell?

Answer 1

Sensory component of post synpatic cell (Soma, dendrites)

Question 2

What is IPSP? EPSP?

Answer 2

Inhibitory post synaptic potential

Excitatory post synaptic potential

Question 3

Name the EPSP neurotransmitters?

Answer 3

Acetylcholine
ATP
Serotonin
Glutamate

Question 4

Name the IPSP neurotransmitters

Answer 4

GABA

Glycine

Question 5

Name 3 ionotropic receptors

Answer 5

GABA/Gly/nAch
Glutamate
Purine

Question 6

Are ion channels linked to ionotropic receptors hetereomeric?

Answer 6

Yes

Either 4 or 5 subunits to make 1 channel

Question 7

Are ion channels selective for Cl-?

Answer 7

No

Question 8

Where is the ligand binding site located on purine receptors?

Answer 8

Extracellular C termini loop

Question 9

How many times does the nAch/GABA/Gly receptor pass through the membrane?

Answer 9

4

Question 10

How many subunits form the ion channel linked to nAch/Gly/GABA?

Answer 10

5

Question 11

What is the primary inhibitory neurotransmitter in central nervous system (brain)?

Answer 11

GABA

Question 12

Which receptor binds alcohol, barbiturates and benzodiazepines?

Answer 12

GABA

Question 13

What is the inhibitory neurotransmitter in the spinal cord other than GABA?

Answer 13

Glycine

Question 14

What muscles does glycine target?

Answer 14

antagonist muscles

Question 15

How many times does the glutamate receptor pass through the membrane?

Answer 15

3

Question 16

How many subunits compose the ion channel that is linked to the glutamate receptor?

Answer 16

4 or 5

Question 17

What ion channels is glutamate linked to?

Answer 17

Na+

K+

Question 18

What receptor/ion channels are permeable to Ca+?

Answer 18

NMDA/AMPA

Question 19

Why does NMDA require partial depolarization before opening Ca+ ion channels?

Answer 19

Remove Mg2+

Question 20

What are NMDA channels inhibited by?

Answer 20

Ketamine and PCP

Question 21

Is the nACh receptor excitatory or inhibitory?

Answer 21

Excitatory

Question 22

Is the Glycine receptor inhibitory or excitatory?

Answer 22

Inhibitory

Question 23

Is the GABA receptor inhibitory or excitatory?

Answer 23

Inhibitory

Question 24

What are HT3R receptors?

Answer 24

Similar to nAch/GABA/Gly

Question 25

Where do ligand gated receptors bind ligands?

Answer 25

Extracellular

Question 26

Which subunit of the nAch/GABA/Gly receptor forms the aqueous pore/ion channel and is responsible for ion selectivity?

Answer 26

M2

Question 27

What is the purpose for the intracellular portion of the subunit topology of nAch, HT3R, GABA, Gly?

Answer 27

processing, targeting, anchoring

Question 28

Do Glutamate and purinergic receptors share the same topology as Gly/GABA/nAch?

Answer 28

No

Question 29

How many alpha subunits are present in nAch?

Answer 29

2

Question 30

Why is succinylcholine used during surgery?

Answer 30

Activates nAchR but then inactivates to prevent muscle contraction during surgery

Question 31

Name an agonist for nAch

Answer 31

Trimethaphan

Question 32

Which subunits determine subunit affinity and bind the ligand?

Answer 32

Alpha

Question 33

What is the purpose for each alpha subunit to have a binding site?

Answer 33

Both must be bound for activation

Question 34

Which subunit likely determines localization of nAchR?

Answer 34

Beta

Question 35

What is the membrane potential for K+, Cl-, Cations, Na+?

Answer 35

-90 -68 -3 +60

Question 36

If 2 ions are both considered dominant, what are their respective permeabilities?

Answer 36

1

Question 37

What neurotransmitter is related to the HT3R receptor?

Answer 37

Serotonin

Question 38

Why are antagonists (Dolasetron) of HT3R important?

Answer 38

Anti-diarrhea/nausea