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Physiology > Ligand gated ion channels II > Flashcards

Ligand gated ion channels II Flashcards

1
Q

Glycine receptor is a heteropentamer, how many alpha subunits does it have?

A

3

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2
Q

What are agonists of the glycine receptor? Antagonists?

A

Glycine, Taurine

Strychnine

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3
Q

Where does ligand binding occur on the glycine receptor?

A

N terminus of alpha subunit

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4
Q

What ion is glycine permeable to?

A

Chloride

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5
Q

What modification regulates activity of glycine receptor?

A

Phosphorylation (PKA,PKC, Tyrosine kinase)

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6
Q

How many alpha subunits does GABA have?

A

2

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7
Q

What is the intracellular enzyme involved in targeting for Gly and GABA receptors?

A

Gephyrin

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8
Q

What is the cause of stiff baby syndrome?

A

Mutation in Gly targeting

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9
Q

What happens when Gly/GABA receptors are activated?

A

membrane potential is slightly depolarized (-77mV)

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10
Q

What happens when Gly/GABA receptors are activated along with Ach receptors?

A

Depolarization is less than is would be with Ach alone

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11
Q

How is Gly inhibitory?

A

Stabilizes membrane potential and reduces depolarization during cation permeability

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12
Q

What is the purpose for multiple binding sites?

A

No incidental activation

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13
Q

If a receptor has 3 binding sites, and 33% are occupied, what % is open?

A

4%

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14
Q

What is the presynaptic uptake receptor for Glycine?

A

GlyT2

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15
Q

What is the perisynaptic uptake receptor for Glycine?

A

GlyT1

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16
Q

What is the presynaptic uptake enzyme for GABA? Perisynaptic?

A

GAT1

GAT3

17
Q

What is the enzyme that breaks down acetylcholine?

A

Cholinesterase

18
Q

What is the enzyme that breaks down serotonin?

A

Monoamine oxidase

19
Q

What is the uptake receptor for serotonin?

A

SERTs

20
Q

What modifications to receptors result in a termination of response?

A

Dissociation
Desensitization
Down regulation

21
Q

What are the ways transmitters can be removed?

A

Breakdown/metabolism
Diffusion from cleft
Reuptake

22
Q

Why does glycine hyperpolarize if the math says depolarization should occur?

A

Stabilizes nerve cell to prevent signal propagation (action potential reduction)

23
Q

What is the result of an inverse agonist?

A

Basal activity is reduced

24
Q

In the parasympathetic pathway the first neurotransmitter is what, and the second transmitter is what?

A

Acetylcholine

Acetycholine

25
Q

In the sympathetic pathway, the first neurotransmitter is what and the 2nd transmitter is what?

A

Acetylcholine

Epinephrine

Physiology (45 decks)

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