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Physiology > Antimicrobial peptides > Flashcards

Antimicrobial peptides Flashcards

1
Q

WHat is OneHealth?

A

Combination of human and animal health

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2
Q

What did the Lederberg experiment determine?

A

Mutations are random

Penicilin resistant bacteria were already present before exposure to penicilin

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3
Q

Are neutrophils anti-microbial peptides?

A

Yes

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4
Q

Describe antimoicrobial peptide killing

A

Defensins are produced within immune cell and line the outermembrane of the organism, form a channel in to the organism and then create pore to breakdown organism

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5
Q

What type of defensins exist?

A

Alpha
Beta
THeta

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6
Q

What is a cathelicidin?

A

Antimicrobial peptide found inside macrophages, PMNs, keratinocytes

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7
Q

What are the porcine cathlecidins?

A

PR-39

PG-1 to 5

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8
Q

What are the bovine cathelicidins

A

Bac-4
Bac-5
Bac-7

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9
Q

What is a human cathelicidin?

A

LL-37

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10
Q

What is a procine Beta defensin?

A

pBD-1

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11
Q

What are bovine beta defensins?

A

TAP

LAP

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12
Q

What is an example of an alpha-defensin?

A

Human neutrophil Peptide 3

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13
Q

What is an example of a theta defensin?

A

Rhesus RD-1

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14
Q

What are the mini defensins?

A

Retrocyclin
Rhesus TD-1
Protegrin-1

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15
Q

How are cathelicidins organized?

A

Based on common patterns of cysteine residues

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16
Q

Where are alpha-defensins found? What intestinal cell has alpha-defensins?

A

Neutrohpils, urogenital tract

Paneth cells

17
Q

Do Paneth cells exist in pigs?

A

No

18
Q

What cell makes both cathelicidins and defensins?

A

Neutrophils

19
Q

What is the main function of defensins and cathelicidins?

A

Protection from broad range of bacteria, fungi, viruses and metazoan parasites

20
Q

What are the main mechanisms by which cathelicidins and defensins are antimicrobial?

A

Pore formation
LPS-binding
Interference with intracellular metabolism

21
Q

Can pathogens become resistant to this innate immune function?

A

It is difficult because they work via cell-surface biochemistry which is well conserved

Physiology (45 decks)

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