Hepcidin Flashcards
WHat controls iron absorption, storage and tissue distribution to plasma?
Hepcidin and ferroportin
What is the receptor for hepcidin?
Ferroprotin
How is hepcidin regulated?
Iron concentration feedback from plasma, liver, and erythropoietic demand
Why is anemia sometimes associated with infections or inflammatory disorders?
Hepcidin and ferroprotin are modulated to decrase availability of iron to pathogens but may also restrict iron to erythropoietic precursors.
What are antimicrobial peptides?
Gene-coded cationic peptides
How many disulfide bonds do defensins have?
3
Is hepcidin present in plants and animals?
Yes
How many disulfide bonds does
4
What induces hepcidin in catfish? What inhibits hepcidin?
Infection
Anemia
What induces hepcidin expression in frogs?
Hypothermia and iron overload
How conserved is hepcidin?
Extremely
Where is most hepcidin expressed?
Liver
How does anemia affect hepcidin expression?
Inhibits hepcidin expression
How does percent saturation of transferrin affect hepcidin?
High levels of saturation upregulate hepcidin expression
Does bacterial infection increase or decrease hepcidin expression?
Increase
What is an orthologous gene?
Different species, same gene
What is a paralogous gene?
Isoforms of genes in 1 species
Name a housekeeping gene
18s RNA
How are tHEP1 and tHEP2 similar?
Three exons & 2 introns
Similar peptide sequence
Gene organization
Expression pattern
How does tHEP2 differ from tHEP1 during iron overloading?
tHEP2 increases
tHEP1 does not
Does tHEP2 or tHEP1 decrease during response to corticosterone?
tHEP1
