Neurotransmitter receptors & pharmacology

Question 1

Name 2 cholinergic receptors

Answer 1

Nicotinic

Muscarinic

Question 2

Where do M2 receptors appear?

Answer 2

Parasympathetic postganglionic

Question 3

What are some effects of M2 activation?

Answer 3

Vasodilation (flush)
DIlation of pupil
Decrease salivation
Decreased perspiration
Hallucinations

Question 4

Acetylcholine is a physiological agonist. Is it selective or non-selective?

Answer 4

Non-selective

Question 5

Name a nicotinic ganglionic antagonist (Ng)?

Answer 5

Hexamethonium

Question 6

Name a nicotinic neuromuscular depolarizing blocker (Nm)

Answer 6

Decamethonium

Succinylcholine

Question 7

What is the lock and key model of neurotransmitters?

Answer 7

Agonist binding to receptor causes conformational shift of receptor

Question 8

How do antagonists bind to inhibit receptors?

Answer 8

Antagonists have similar structure to agonist but do not induce necessary conformation changes

Question 9

What receptor is Gs/cAMP linked to?

Answer 9

B-adrenergic

Question 10

What receptor is Gi/cAMP linked to?

Answer 10

M2 Muscarinic

Question 11

What receptor is Gq/IP3/DAG linked to?

Answer 11

alpha1-adrenergic

Question 12

What receptor is Gq/NO/cGMP linked to?

Answer 12

H1 histaminergic

Question 13

Which receptors are linked to tyorsine kinase receptors?

Answer 13

Dopamine, NMDA

Question 14

What occurs when there are multiple receptor sites at a single synpase during polarized conditions?

Answer 14

Presynaptic M2 receptors have a high affinity for Ach and occupied receptors are linked to synaptic vesicles to reduce exocytosis. Postaynaptic nicotinic receptors are unoccupied and closed

Question 15

What occurs when there are multiple receptor sites at a single synapse during depolarized conditions?

Answer 15

Presynaptic M2 receptors have a low affinity for Ach. Ach dissociates from vesicles. VOltage-gated Ca2+ channels open and allow vesicle fusion & exocytosis

Question 16

What occurs when there are multiple receptor sites at a single synapse during repolariztion?

Answer 16

Presynaptic M2 receptors and postsynaptic nicotinic receptors have high affinity for Ach. Occupied presynaptic receptors are linked to vesicles to reduce exocyotsis

Question 17

What is the effect of Beta1 on heart rate?

Answer 17

Increase

Question 18

What is the effect of Beta1 on heart contractility?

Answer 18

Increase

Question 19

What is the effect of Beta2 on bronchi?

Answer 19

Dilate

Question 20

What receptor does Atenolol act on?

Answer 20

Beta1 blocker

Question 21

What receptor does Propanolol act on?

Answer 21

Beta1 agonist, Beta2 blocker

Question 22

What receptor does prazosin act on?

Answer 22

Alpha1 blocker

Question 23

What receptor does phenylephrine act on?

Answer 23

Alpha1 agonist

Question 24

What receptor does Dobutamine act on?

Answer 24

Beta1 agonist

Question 25

What receptor does Albuterol act on?

Answer 25

beta2 agonist

Question 26

What receptor does norepinephrine act on?

Answer 26

Alpha1, Alpha2, Beta1 agonist

Question 27

How to association constant?

Answer 27

Kd = Koff / Kon

Question 28

How to calclate affinity?

Answer 28

affinity = association rate (Kon) * [ligand]

Question 29

What is the neurotransmitter for the cholinergic receptor? Where is it found?

Answer 29

Acetylcholine

Neromuscular junctions

Question 30

What is the neurotransmitter for biogenic amines? Where is it found?

Answer 30

Norepinephrine

sympathetic postganglion

Question 31

What is the neurotransmitter for amino acid receptors? WHere is it found?

Answer 31

Glutamate, GABA

CNS

Question 32

What is the neurotransmitter for peptide receptors? where is it found?

Answer 32

Substance P

CNS

Question 33

What is the neurotransmitter for purine receptors? where is it found?

Answer 33

ATP

CNS

Question 34

What are metabotropic receptors?

Answer 34

G-protein linked & tyrosine kinase linked receptors