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Physiology > Neurotransmitter receptors & pharmacology > Flashcards

Neurotransmitter receptors & pharmacology Flashcards

1
Q

Name 2 cholinergic receptors

A

Nicotinic

Muscarinic

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2
Q

Where do M2 receptors appear?

A

Parasympathetic postganglionic

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3
Q

What are some effects of M2 activation?

A 
Vasodilation (flush)
DIlation of pupil
Decrease salivation
Decreased perspiration
Hallucinations
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4
Q

Acetylcholine is a physiological agonist. Is it selective or non-selective?

A

Non-selective

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5
Q

Name a nicotinic ganglionic antagonist (Ng)?

A

Hexamethonium

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6
Q

Name a nicotinic neuromuscular depolarizing blocker (Nm)

A

Decamethonium

Succinylcholine

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7
Q

What is the lock and key model of neurotransmitters?

A

Agonist binding to receptor causes conformational shift of receptor

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8
Q

How do antagonists bind to inhibit receptors?

A

Antagonists have similar structure to agonist but do not induce necessary conformation changes

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9
Q

What receptor is Gs/cAMP linked to?

A

B-adrenergic

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10
Q

What receptor is Gi/cAMP linked to?

A

M2 Muscarinic

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11
Q

What receptor is Gq/IP3/DAG linked to?

A

alpha1-adrenergic

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12
Q

What receptor is Gq/NO/cGMP linked to?

A

H1 histaminergic

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13
Q

Which receptors are linked to tyorsine kinase receptors?

A

Dopamine, NMDA

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14
Q

What occurs when there are multiple receptor sites at a single synpase during polarized conditions?

A

Presynaptic M2 receptors have a high affinity for Ach and occupied receptors are linked to synaptic vesicles to reduce exocytosis. Postaynaptic nicotinic receptors are unoccupied and closed

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15
Q

What occurs when there are multiple receptor sites at a single synapse during depolarized conditions?

A

Presynaptic M2 receptors have a low affinity for Ach. Ach dissociates from vesicles. VOltage-gated Ca2+ channels open and allow vesicle fusion & exocytosis

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16
Q

What occurs when there are multiple receptor sites at a single synapse during repolariztion?

A

Presynaptic M2 receptors and postsynaptic nicotinic receptors have high affinity for Ach. Occupied presynaptic receptors are linked to vesicles to reduce exocyotsis

17
Q

What is the effect of Beta1 on heart rate?

A

Increase

18
Q

What is the effect of Beta1 on heart contractility?

A

Increase

19
Q

What is the effect of Beta2 on bronchi?

A

Dilate

20
Q

What receptor does Atenolol act on?

A

Beta1 blocker

21
Q

What receptor does Propanolol act on?

A

Beta1 agonist, Beta2 blocker

22
Q

What receptor does prazosin act on?

A

Alpha1 blocker

23
Q

What receptor does phenylephrine act on?

A

Alpha1 agonist

24
Q

What receptor does Dobutamine act on?

A

Beta1 agonist

25
Q

What receptor does Albuterol act on?

A

beta2 agonist

26
Q

What receptor does norepinephrine act on?

A

Alpha1, Alpha2, Beta1 agonist

27
Q

How to association constant?

A

Kd = Koff / Kon

28
Q

How to calclate affinity?

A

affinity = association rate (Kon) * [ligand]

29
Q

What is the neurotransmitter for the cholinergic receptor? Where is it found?

A

Acetylcholine

Neromuscular junctions

30
Q

What is the neurotransmitter for biogenic amines? Where is it found?

A

Norepinephrine

sympathetic postganglion

31
Q

What is the neurotransmitter for amino acid receptors? WHere is it found?

A

Glutamate, GABA

CNS

32
Q

What is the neurotransmitter for peptide receptors? where is it found?

A

Substance P

CNS

33
Q

What is the neurotransmitter for purine receptors? where is it found?

A

ATP

CNS

34
Q

What are metabotropic receptors?

A

G-protein linked & tyrosine kinase linked receptors

Physiology (45 decks)

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