The Digestive System And Metabolism 14 Flashcards
Ingestion
Taking in food
Digestion
Breaking food into nutrient molecules
Absorption
Movement of nutrients into bloodstream
Defecation
Getting rid of indigestible waste
Groups of digestive organs
1.Alimentary canal
2. Accessory digestive organs
Alimentary canal GI tract
Continuous hollow tube that helps ingest, digest, absorb, defecate (mouth to anus )
Accessory digestive organs
Assist in digestion in various ways
Teeth, tongue and other big digestive organs (liver pancreas, gallbladder)
Organs of alimentary canal
Mouth
Pharynx
Esophagus
Stomach
Small intestine
Large intestine
Anus
Mouth (oral cavity) lined with
Mucous membrane lined cavity
Lips (labia)
Protect anterior opening
Cheeks
Form the lateral walls
Hard palate
Forms anterior roof
Soft palate
Forms posterior roof
Uvula
Fleshy projection of soft palate
Vestibule
Space between lips externally and teeth and gums internally
Oral cavity proper
Area contained by teeth
Tongue attached by
Attached at hyoid bone and styloid processes of skull
Attached by lingual frenulum to floor of mouth
Palatine tonsils
@ posterior end of oral cavity
Lingual tonsil
At base of tongue
Gingivae
Gums
Functions of mouth
1.Mastication
2. Mixes chewed food with saliva
3.tongue initiates swallowing
4. Tastebuds on tongue allow for taste
Pharynx function in eating
Passage for food, fluid, air
Food passes to from the mouth posteriorly to the
Oropharynx
Laryngopharynx
Location of Laryngopharynx
Under oropharynx
Continuous with esophagus
Food is propelled to esophagus by two layers of skeletal muscle in pharynx
Longitudinal outer layer
Circular inner layer
What propels food?
Peristalsis
Alternating contractions of muscle layers
Anatomy of esophagus
10 inches long
Runs from pharynx to stomach through diaphragm
Physiology of esophagus
- Uses peristalsis to take food to stomach
2.passageway for food only. (Resp system branches off after pharynx(
Layers of tissue that make alimentary canal organs (innermost to outermost)
- Mucosa
- Submucousa
- Muscularis externa
4.serosa
Lines cavity aka lumen
Innermost, moist membrane
Mucosa
Mucosa made of
1.Surface epithelium that’s mostly simple columnar
Esophagus made of stratified squamous
- Small amount of connective tissue (lamina propria)
- Scanty smooth muscle layer
Submucousa
- Under mucosa
- Soft, connective tissue w/ blood vessels, nerve endings, mucosa Associated Lymphoid tissues, lymphatic vessels
Muscularis externa
Smooth muscle
Inner circular layer, outer longitudinal layer
Serosa
Outermost layer of wall; contains fluid producing cells
Visceral peritoneum of serosa
Innermost layer continuous with outermost layer
Parietal peritoneum of serosa
Outermost layer that lines the abdominopelvic cavity by way of the mesentery
Alimentary Wall canals have 2 intrinsic nerve plexuses
Submucosal nerve plexus
My enteric nerve plexus
Function of alimentary canal nerve plexuses
Regulate mobility and secretory activity of GI tract organs
Submucosal nerve plexus
Controls glandular secretions
Electrolyte and water transport
Blood flow
Myenteric nerve plexus
Peristaltic movement of bowels
C-shaped organ on left side of abdominal cavity
Stomach
Food enters the stomach from
Cardioesophageal sphincter from the esophagus
Food from stomach empties into the small intestine from
Pyloric sphincter (valve)
Regions of the stomach
- Cardial
2.Fundus
3.Body
4.Pylorus
Cardia (cardial)
Near heart
Surrounds the cardioesophageal sphincter
Fundus
Expanded portion lateral to cardiac region
Body
Mid portion
Greater curvature of stomach Body
Convex lateral surface
Lesser curvature of stomach Body
Concave medial surface
Pylorus
Funnel shaped terminal end of stomach
Empties into duodenum
Stomach can stretch and hold what capacity of food when full?
4L (1 gal)
Rugae
Internal folds of mucosa present when stomach is empty
Lesser omentum
Double layer of peritoneum
Extends from liver to lesser curvature of stomach
Greater omentum
1.Another extension of peritoneum
2.Covers abdominal organs
3.Fat insulates, cushions and protects abdominal organs
What kind of cells make stomach mucosa
Simple columnar epithelium made of mucous cells
Describe mucus produced by mucous cells?
Bicarbonate-rich alkaline mucous
The stomach mucosa is dotted by
Gastric pits leading to gastric glands that secrete gastric juices
Intrinsic factor
Needed for vitamin B-12 absorbtion for small intestine
What secretes intrinsic factor?
Gastric pits
Chief cells
Make protein digesting enzymes
Secrete pepsinogen
Pepsinogens
Protein digesting enzymes
Parietal cells
Make HCL acid that activates enzymes
Mucous neck cells
Make thin acidic mucus (different from mucus made by mucous cells of the mucosa)
Enteroendocrine cells
Produce local hormones such as gastrin
Pepsinogen is known as inactive form, becomes active when
Comes in contact with HCL made by parietal cells
Pepsin is active form of
Pepsinogen
Functions of stomach
1.Temporary storage tank for food
2. Site of food breakdown
3. Chemical breakdown of protein begins
4. Delivers chyme to small intestine
Chyme
Processed food
Body’s major digestive organ
Small instestine
Longest portion of alimentary tube + length
Small instestine
2-4m, or 7-13 ft in living person
Small intestine function
Site of nutrient absorption in the blood
Small intestine extends from
Pyloric sphincter to ileocecal valve
Small instestine is suspended from
Posterior abdominal wall by the mesentery
Subdivisions of small intestine
Duodenum
Jejunum
Ileum
Chemical digestion begins in the
Small intestine
Steps of chemical digestion
- Enzymes from intestinal cells and pancreas carried to duodenum by pancreatic ducts
Bile, formed by liver enters the ______ via the ____ _______
Duodenum
Bile duct
Location where main pancreatic duct and bile ducts join
Hepatopancreatic ampulla
Purpose of structural modifications in small intestine
Increase surface area for food absorption
Decrease in number towards end of small intestine
Vili
Fingerlike projections formed by the mucosa
House a capillary bed and lacteal
Villi
Microvilli
Tiny projections of the plasma membrane
(Brush border enzymes)
Circular folds
Plicae circulares
Deep folds of mucosa and submucosa
Peyer’s patches
Collections of lymphatic tissues in small intestine
In which layer are peyer’s patches located?
Submucousa
Increase in number towards end of the small intestine (more in ileum)
Peyer’s patches
Why do we need more peyer’s patches towards the end of the small intestine?
Remaining food residue contains much bacteria
Lacteal
Lymphatic vessel that carries fat from intestines
Why is the large intestine called the large intestine?
Larger in diameter, but it’s shorter in length at 1.5 m
Large intestine extends from
Ileocecal valve to the anus
Subdivisions of large intestine
Cecum
Appendix
Colon
Rectum
Anal canal
Saclike first part of large intestine?
Cecum
Hangs from cecum
Appendix
Appendix
Accumulation of lymphoid tissue that sometimes becomes inflamed
Appendicitis
Inflamed Lymphoid tissu e
Ascending colon
Travels up right side of abdomen and makes turn at right colic (hepatic) flexure
Transverse colon
Across abdominal cavity turns at left colic (splenic) flexure
Descending colon
Travels down left side
Sigmoid colon
S shaped region
Enters pelvis
What parts of large intestine are in the pelvis?
Sigmoid colon
Rectum
Anal canal
Anal canal ends at the
Anus
Anus
Opening of large intestine
External anal sphincter
Formed by skeletal muscle, voluntary
Internal anal sphincter
Formed by smooth muscle and is involuntary
Anal sphincters are normally closed except during
Defecation
Large instestine delivers indigestible food residues to the body’s
Exterior
Produce alkaline mucus to lubricate passage of feces
Goblet cells
Muscularis externa is reduced to 3 bands of muscle known as
Teniae coli
What do the teniae coli do?
Cause wall to pucker into haustra (pocket-like sacs)
Accessory digestive organs
Teeth
Salivary glands
Pancreas
Liver
Gallbladder
Deciduous teeth
Baby teeth
A baby has __ teeth by age 2
20
First teeth to appear are the
Lower central incisors
Permanent teeth replace deciduous teeth between ages
6-12
A full set is ____ teeth (with the wisdom teeth)
32
Incisors
Cutting
Canines (eye teeth)
Tearing or piercing
Premolars (bicuspids)
Grinding
Molars
Grinding
Two major regions of a tooth
Crown and root
Crown
Exposed part of tooth above gingiva (gum)
Enamel
Covers the crown
Dentin
Deep to enamel, makes bulk of tooth, surrounds pulp cavity
Pulp cavity
Contains connective tissue, blood vessels and nerve fibers (pulp)
Root canal
Where pulp cavity extends into the root
Hardest part of teeth and within body
Enamel
Root-cement
Covers outer surface
Attaches tooth to periodontal membrane (ligament)
Root- Periodontal membrane
holds tooth in place in the bony jaw
Connector between crown and root
Neck
Region in contact with gum
Neck
Three pairs of salivary glands that empty secretions into mouth
- Parotid glands
- Submandibular glands
- Sublingual glands
Parotid glands
Found anterior to ears
Mumps affect these salivary glands
Empty saliva into the floor of the mouth through small ducts
Submandibular and sublingual glands
Largest salivary glands
Parotid glands
Mixture of mucus and serous fluid
Saliva
Saliva function
Helps moisten and bind food together into a mass called bolus
Dissolves chemicals so they can be tasted
Salivary amylase
Begins starch digestion
Lysozymes and antibodies in saliva
Inhibit bacteria
Bolus
Mass of bound, chewed food
Soft, pink, triangular gland
Pancreas
Location of pancreas
Behind parietal peritoneum, mostly retroperitoneal
Pancreas extends from
across abdomen from spleen to duodenum
Produces a wide spectrum of digestive enzymes that break down all categories of food
Pancreas
Pancreas Secretes enzymes into
Duodenum
Alkaline fluid introduced with pancreas enzymes does what?
Neutralizes acidic chyme coming from stomach
Hormones produced by pancreas
Insulin
Glucagon
Largest gland in the body
Liver
Liver location
Right side of body under diaphragm
Liver parts
4 lobes suspended from diaphragm and abdominal wall by falciform ligament
Digestive role of liver
Produce bile
Bile leaves liver through the
Common hepatic duct an then it enters duodenum through the bile duct
Bile
Yellow-green watery solution
Bile contains
1.Bile salts and bile pigments (mostly bilirubin from the breakdown of hemoglobin
- Cholesterol, phospholipids and electrolytes
What does bile do?
Break down fats
(Emulsifies)
Gallbladder location and appearance
Green sac
In shallow fossa on bottom of liver
When no digestion happens what happens in gallbladder?
Bile backs up in cystic duct for storage in gallbladder
While in the gallbladder, bile is concentrated by the
Removal of water
When fatty food enters the duodenum, what does the gallbladder do?
Spurts out stored bile
GI processes and controls are responsible for
Digestion and absorption
Propulsion
Moving food from one region of the digestive system to another
Alternating waves of contraction and relaxation that squeeze food along the GI tract
Peristalsis
Segmentation
Movement of materials back and forth to foster mixing in small intestine
Examples of mechanical breakdown
Mixing food by the tongue
Churning food by the stomach
Segmentation in the small intestine
Why is mechanical digestion important?
Prepares food for further degradation by enzymes
When does digestion occur
When enzymes chemically break down large molecules into their building blocks
Each major food group is broken down by ________ enzymes
Different
Carbohydrates are broken down to ____
Proteins are broken down to ___
Fats are broken down to ____&_____
Carbohydrates broken down to monosaccharides
Proteins broken down to amino acids
Fats broken down to fatty acids and glycerol
Amylase
Breaks down carbs
Breaks down proteins
Peptidase or prolease
Lipases
Break down fats
Carbohydrate digestion starts in _____ with which enzyme ?
The mouth
Salivary amylase
Protein digestion begins in the ____ with which enzyme?
Stomach
With pepsin
Lipids are emulsified by detergent action of
Bile salts from liver
Pancreatic lipase
Absorption
End products of digestion are absorbed in blood or lymph
Food must enter mucosal cells and then move into blood or lymph capillaries
No food absorption occurs in the
Mouth
Explain food ingestion and breakdown
- Food goes in mouth, chewed
- Mixed w/ saliva caused by mechanical pressure and psychic stimuli
- Salivary amylase starts starch digestion
Food propulsion
Swallowing and peristalsis
Pharynx and esophagus have no
Digestive function
Pharynx and esophagus serve as
Passageways to stomach
Deglutition
Swallowing
Pharynx functions in
Swallowing
Two phases of swallowing
Buccal phase
Pharygeal-esophageal phase
Buccal phase
Voluntary
Occurs in mouth
Food made into bolus
Bolus forced into pharynx by tongue
Pharyngeal esophageal phase
1.Involuntary transport of bolus through peristalsis
- Nasal and respiratory passages are blocked
- Bolus moved to stomach
- Cardioesophageal sphincter opens when food is pressed against it
Gastric juice is regulated by
Neural and hormonal factors
Presence of food or rising pH causes the release of
Gastrin
Gastrin causes stomach glands to produce
Protein-digesting enzymes
Mucus
Hydrochloric acid
Acidic pH function
1.Activates pepsinogen to pepsin for protein digestion
- Hostile environment for microorganisms
Rennin
Digesting milk protein in infants; not produced in adults
Only items absorbed in stomach
Alcohol and aspirin
Waves of peristalsis occurred from the ______ to the _____ and force food through
fundus to pylorus
force food through pyloric sphincter
Grinding
Pylorus meters out chyme into the small intestine (3ml at a time)
Retropulsion
Peristaltic waves close the pyloric sphincter, forcing contents back into stomach; stomach empties in 4-6 hours
Chyme breakdown and absorption: Intestinal enzymes from the brush border function to
Break double sugars into simple sugars
Complete some protein digestion
Intestinal enzymes and pancreatic enzymes help to
Complete digestion of all food groups
Play a major role in the digestion of fats proteins and carbohydrates
Pancreatic enzymes
______ content neutralizes the acidic chyme and provides the proper environment for pancreatic enzymes to operate
Alkaline
Stimulates the release of pancreatic juice into the duodenum
Vagus nerve
Secretin
Cholescystokinin (CCK)
Hormones (secretin and cck) also Target the liver and gallbladder to release
Bile
Needed for absorption of fat soluble vitamins a d e k
Bile
Chyme
Bolus + gastric juices
Steps of regulation of pancreatic juice and bile
- Chyme entering duodenum causes cells to secrete cholescystokinin and secretin
- Cck and secretin enter bloodstream
- When they reach pancreas, cck causes secretion of enzyme rich pancreatic juice. Secretin causes secretion of bicarbonate rich pancreatic juice
- Causes liver to secrete more bile, cck stimulates the gallbladder to release stored bile .
Hepatopancreatic sphincter relaxesto allow bile to enter from both sources into duodenum - Stimulation by vagus nerve fibers causes release of pancreatic juice and weak contractions of gallbladder
Gastrin
Stimulates release of gastric juice
Stimulate stomach emptying
Intestinal gastrin
Stimulates gastric secretion and emptying
Histamine
activates parietal cells of stomach to secrete hydrochloric acid
Somatostatin
Inhibits secretion of gastric juice and pancreatic juice
Inhibits emptying of stomach and gallbladder
Secretin
Increases output of pancreatic juice rich in bicarbonate ions
Increases bile output by liver
Inhibits gastric mobility and gastric gland secretion
CCK cholecystokinin
Increases output of enzyme rich pancreatic juice
Stimulates gallbladder to expel stored bile
Releases sphincter of duodenal papilla to allow bile and pancreatic juice to enter the duodenum
Gastric inhibitory peptide
Inhibit secretion of gastric juice
Stimulates insulin release
Water is absorbed along the length of
Small intestine
End products of digestion absorbed by
Most substances absorbed through active transport
Lipids absorbed by diffusion
Substances are transported to the liver by
The hepatic portal vein
Lymph
Major means of moving food
Peristalsis
Chyme propulsion
Segmental movements function
Mix chyme with digestive juices
Aid in propelling food
No digestive enzymes are produced during
Nutrient breakdown and absorption
The resident bacteria digest the remaining nutrients
How do bacteria digest remaining nutrients
Produce vitamin K vitamin B and release gases
Water, vitamins, ions absorbed during
Nutrient breakdown and absorption
Feces contains
Undigested food residues
Mucus,
Bacteria,
Water
Propulsion of food residue and defecation
- Sluggish peristalsis begins when food residue arrives
- Haustral contractions are movements occuring most frequently in large intestine
- Mass movements are slow powerful movements that occur 3 to 4 times a day
Haustral contractions
Most frequent movements in the large intestine
Slow powerful occur 3 to 4 times a day
Presence of feces and rectum causes a defecation reflex meaning
The anal sphincter is relaxed
Defecation occurs with the relaxation of the voluntary or external anal sphincter
Energy value of food is measured in
Kcal or Calories (C)
Chemical energy that drives cellular activities
Food oxidized into
Adenosine tri-phosphate
Nutrient
Substance used by the body for growth, maintenance and repair
Which are the major nutrients
Carbohydrates lipids proteins and water
Which are the minor nutrients
Vitamins and minerals
Diet consisting of _ food groups guarantees adequate amounts of all needed nutrients
5
Glycogenesis
Formation of glycogen by liver
Falciform ligament
thin, sickle-shaped, fibrous structure that connects the anterior part of the liver to the ventral wall of the abdomen
Haustra
saccules in the colon that give it its segmented appearance
Reverse peristalsis
Emesis
Serious inflammatory condition in which the colon mucosa protrudes through the colon wall is called
Diverticulitis
What carries excess cholesterol from body cells to liver
HDL
Gluconeogenesis
Making glucose from amino acids and fats
Hormone secreted by the duodenum inhibits secretion of gastric juices and stimulates the release of insulin
Gastric inhibitory peptide
Could be a contributor to pancreatitis
Chymotrypsin
Which Hormone is most responsible for the determining the basal metabolic rate
Thyroxine