Tetracylines

Question 1

What is one of the oldest groups of antibiotics?

Answer 1

tetracycline

Question 2

*What animals are tetracyclines mostly used in?

Answer 2

large animals

Question 3

Examples of tetracycline

Answer 3

a. Tetracycline
b. Oxytetracycline
c. Doxycycline

Question 4

How does this drug work against bacteria?

Answer 4

disrupts protein synthesis by binding to bacterial ribosomes

Question 5

How does tetracycline absorb in the body?

Answer 5

• oral

- parenteral

Question 6

*What products interfere with absorption of tetracycline from the GI tract?

Answer 6

1. dairy products
2. antidiarrheal agents
3. antacids

Question 7

*How does dairy interfere with absorption of tetracycline?

Answer 7

Calcium binds with the drug molecule and effects its ability to absorb

Question 8

How is tetracycline distributed in the body?

Answer 8

1. most tissues

2. not CNS

Question 9

*How is tetracycline eliminated from the body?

Answer 9

1. excreted through bile but most reabsorbed from intestine

2. renal excretion

Question 10

*What is tetracycline effective against?

Answer 10

1. rickettsia
2. spirochetes
3. chlamydia
4. mycoplasma

Question 11

*What can administration of tetracycline cause in animals?

Answer 11

1. Causes yellow discoloration of teeth and bones in young, growing animals
2. Cause retardation of bone growth in the fetus
3. Vomiting, diarrhea, anorexia

Question 12

What animals should you not use tetracycline on?

Answer 12

animals with renal disease

Question 13

What should you not use tetracyclines in combination with?

Answer 13

1. penicillin
2. cephalosporins
   (bacteriostatic antibiotics)