Aminoglycosides

Question 1

*What type of drug are aminoglycosides?

Answer 1

Powerful G- antibiotic

Question 2

Why are aminoglycosides not generally used in food animals?

Answer 2

Long withdrawal times

Question 3

Examples of aminoglycosides

Answer 3

1. Gentamicin
2. Amikacin
3. Kanamycin
4. Neomycin
5. Streptomycin
6. Tobramycin

Question 4

How are aminoglycosides effective against bacteria?

Answer 4

1. inhibit bacterial protein synthesis by attaching to the bacterial ribosome
2. will kill the bacteria

Question 5

*How are aminoglycosides absorbed in the body?

Answer 5

1. hydrophilic at physiologic pH
2. not well absorbed in GI tract or uterus
3. absorbed well after parenteral administration

Question 6

How are aminoglycosides distributed in the body?

Answer 6

does not penetrate CNS

Question 7

*What can cause toxicity when administering aminoglycosides?

Answer 7

when the drug accumulates in the inner ear tissues and the kidney

Question 8

How are aminoglycosides eliminated from the body?

Answer 8

excreted from the kidney

Question 9

What are aminoglycosides effective against?

Answer 9

1. G-

2. some G+

Question 10

What bacteria should aminoglycosides be used against?

Answer 10

G- bacteria

don’t need to use it for G+ because there are much safer options for G+ bacteria

Question 11

*When should you be cautious when using aminoglycosides?

Answer 11

animals with renal disease or poor renal blood perfusion

Question 12

What aminoglycosides should not be mixed with penicillin in the same syringe?

Answer 12

1. gentamicin
2. amikacin
3. kanamycin
4. tobramycin

Question 13

*What inactivates aminoglycosides?

Answer 13

organic debris

Question 14

What animal should you not use aminoglycosides on?

Answer 14

adult food animals