Anticonvulsants: Phenobarbital

Question 1

What is Phenobarbital?

Answer 1

Most popular anticonvulsant drug for long-term control of seizures

Question 2

How is Phenobarbital distributed? (2)

Answer 2

1. Highly protein bound

2. Aspirin and sulfonamides displace it from proteins

Question 3

How is Phenobarbital biotransformation?

Answer 3

Metabolized in the liver by the same enzymes that metabolize other veterinary drugs

Question 4

What does the therapeutic dose do for Phenobarbital?

Answer 4

varies between individuals

Question 5

What are the common side effects of Phenobarbital? (3)

Answer 5

1. sedation
2. incoordination
3. lethargy

Question 6

What are the rare side effects of Phenobarbital? (2)

Answer 6

1. liver disease

2. anemia

Question 7

What is necessary for therapeutic drug use of Phenobarbital?

Answer 7

drug concentration monitoring necessary