Chloramphenicol

Question 1

*Why are chloramphenicols only used occasionally in animals?

Answer 1

it is a powerful broad spectrum antibiotic that can be very toxic to both animals and humans
(should not be used in food animals)

Question 2

How do chloramphenicols control bacterial growth?

Answer 2

interferes with bacterial ribosomes and protein synthesis

Question 3

How are chloramphenicols absorbed into the body?

Answer 3

oral administration

Question 4

*How are chloramphenicols distributed in the body?

Answer 4

1. all tissues

2. including CNS

Question 5

*What are chloramphenicols effective against?

Answer 5

1. G+ and G-
2. rickettsia
3. chlamydia
4. mycoplasma

Question 6

What are the precautions for using chloramphenicols?

Answer 6

1. can cause bone marrow suppression
2. don’t use in animals with liver disease
3. cats have a hard time metabolizing this drug
4. don’t use with penicillin or cephalosporin

Question 7

Why would you not use chloramphenicol with penicillin or cephalosporin?

Answer 7

you would be mixing a bactericidal drug with bacteriostatic drugs