Systemic Antifungals Flashcards
1
Q
What are the four systemic antifungals?
A
- Griseofulvin
- Ketoconazole
- Itraconazole
- Amphotericin B
2
Q
Where in the body does griseofulvin work best?
A
Reaches high concentrations in skin, hair, and nails
3
Q
When is griseofulvin toxicity possible?
A
Pregnant animals and cats
4
Q
What is griseofulvin used for?
A
Ringworm and other dermatophytes
5
Q
What animals can you use griseofulvin on?
A
Large and small animals
6
Q
What is Ketoconazole and Itraconazole used for?
A
- systemic fungal infections
2. malassezia pachydermitis
7
Q
What are the adverse effects possible with Ketoconazole and Itraconazole?
(5)
A
- anorexia
- vomiting
- diarrhea
- weight loss
- hepatic toxicity
8
Q
What is malassezia pachydermitis?
2
A
- external ear infections
2. skin infections
9
Q
How is Amphotericin B administered?
A
IV or injection
10
Q
What are the adverse effects of using Amphotericin B?
A
liver disease
11
Q
Why is Amphotericin B only used when other drugs have failed?
A
because it is extremely toxic
