Anti-inflammatory: NSAIDs

Question 1

How do NSAIDs work?

Answer 1

Exert their effect by blocking enzymes in the inflammatory cascade

Question 2

How do NSAIDs differ from Glucocorticoids?

Answer 2

produce fewer side effects

Question 3

NSAIDs are _____ bound to plasma proteins?

Answer 3

highly

Question 4

What are the adverse effects on the GI tract? (4)

Answer 4

1. anorexia
2. diarrhea
3. melena (digested blood in feces)
4. ulcer formation

Question 5

Why are there adverse effects on the GI tract?

Answer 5

effect due to decreased protective prostaglandin production (PGE, PGI2)
- protect GI from getting ulcers

Question 6

What do GI prostaglandins do? (4)

Answer 6

1. ↓ volume and acidity of gastric secretions
2. ↑ sodium bicarbonate (NaHCO3) secretions in the intestine
3. ↑ gastric and intestinal mucus production
4. ↑ turnover and repair of GI epithelial cells

Question 7

What are the kidney adverse effects?

Answer 7

renal tissue necrosis

Question 8

What do kidney prostaglandins do for the kidney?

Answer 8

1. health of kidney
2. Decreased blood flow to kidneys causes the kidney prostaglandin to increase the amount of blood able to enter the kidney by dilating the artery