Lincosamides Flashcards
1
Q
*What are lincosamides effective against?
A
G+ anaerobic bacteria
2
Q
Examples of Lincosamides
A
- lincomycin
2. clindamycin
3
Q
*What is clindamycin used for?
A
dental infections
4
Q
How do Lincosamides control bacterial growth?
A
interfere with bacterial protein synthesis
5
Q
How are Lincosamides absorbed in the body?
A
- orally (usually)
2. parenteral
6
Q
How are Lincosamides distributed in the body?
A
- body tissues
2. not CNS
7
Q
Where are Lincosamides metabolized?
A
liver
8
Q
Where are Lincosamides excreted from the body?
A
urine and bile
9
Q
*What is the spectrum of activity for Lincosamides?
A
- G+
- anaerobic bacteria
- some protozoa (toxoplasma)
10
Q
What are the precautions when using Lincosamides?
A
- vomiting and diarrhea
- don’t use antidiarrheals
- do not use in guinea pigs, hamsters, or rabbits
11
Q
Why should you not use antidiarrheals with Lincosamides?
A
Antidiarrheals will coat the lining of the intestines to help minimize irritation and this affects how well an oral drug is absorbed in the GI tract
