Test 2: 8 cancer Flashcards
— is common in cats and huskys and akitas
Eosinophilic Granulomas
Non-Neoplastic, Proliferative & Inflammatory Lesions
Eosinophilic Granulomas look like
Ulcerated Solitary Masses & Plaques
found in the mouth
Eosinophilic granulomatous inflammation with
flame figures
Eosinophilic Granulomas
flame figures
inflammatory lesion in cats and arctic dog breeds
Chronic Lymphocytic Plasmacytic-
Gingivitis-Stomatitis (LPGS) Complex occurs in
cats
88% have feline herpes or feline calicivirus
what does Chronic Lymphocytic Plasmacytic-
Gingivitis-Stomatitis (LPGS) Complex look like
Gingiva & buccal mucosa (Caudal pharynx, tonsil region!)
* Raised, thickened, hyperemic plaques → erosion and ulcers
associated with Feline Odontoclastic Resorptive Lesions (FORL)
LPGS is associated with
Feline Odontoclastic Resorptive Lesions (FORL)
most cases also have feline herpes and feline calici
LPGS cause severe submucosal —-
lymphoplasmacytic
infiltrates that lead to erosion and ulcers
may be hypersensitivity rxn or immune mediated
cat
Chronic Lymphocytic Plasmacytic-
Gingivitis-Stomatitis (LPGS)
Papular Stomatitis
ORF in camelids
caused by parapoxviruses
Papular Stomatitis is caused by
Parapoxviruses- Zoonontic
pathogenesis of papular stomatitis (ORF)
- Epithelial cell infection → Virus-induced hyperplasia &
dysplasia → Epithelial degeneration → Inflammation- expands
submucosa / dermis too! → Pustules, ulcers & crusts
bovine viral papular stomatitis
caused by parapoxvirus
— can spontaneously regress
papillomas
stimulate cytotoxic T cell response
papilloma lesion has —stratified squamous
epithelium (+/- viral inclusions)
Hyperplastic & dysplastic
papillomas are caused by
virus
congenital
idiopathic
papillomas look
big, cauliflower masses on the mouth or lips
multiple or solitary
Exophytic, verrucous
papillomas are benign or metastatic
benign neoplasms
Fibrogingival Hyperplasia (FGH)
benign- found in older boxers
papillomas are common in — animals
younger
— benign neoplasm is Associated with chronic
gingivitis/periodontal dz!
Fibrogingival Hyperplasia (FGH)
differential for Fibrogingival Hyperplasia (FGH)
Peripheral
Odontogenic Fibroma (POF)
Fibrogingival Hyperplasia (FGH) looks
firm smooth nodules
older dogs
FGH cause — histo
Hyperplastic mucosa Hyperplastic
Proliferative fibrovascular
Mucosa tissue
Peripheral Odontogenic Fibroma (POF) is a neoplasm of
the periodontal ligament
older dogs
previously called epulis/epulides
Peripheral Odontogenic Fibroma (POF) are metastatic or benign
benign neoplasm of the periodontal ligament
what do Peripheral Odontogenic Fibroma (POF) look like
benign proliferative mass near teeth
large and firm
pedunculated or sessile
looks similar to FGH or acanthomatous ameloblastoma
histo of Peripheral Odontogenic Fibroma (POFs)
Peripheral Odontogenic Fibroma
Periodontal ligament-like stroma
Acanthomatous Ameloblastoma (AA) has —, but post surgical recurrence is common
no metastasis
aggressive neoplasm
infiltrates bone- difficult to get good margin
Acanthomatous Ameloblastoma (AA) grossly resembles
benign
fibrogingival hyperplasia or POF
histro of Acanthomatous Ameloblastoma (AA)
neoplasm driven by odontogenic epithelium (ameloblasts) →opposite of POFs
cords and solid sheets of neoplastic ameloblasts(cells which secrete the enamel proteins) +/- osseous & dentinous elements
Acanthomatous Ameloblastoma (AA)
could be POF- need histo to determine
Oral Melanoma are benign or malignant?
malignant- very poor prognosis
rapid metastasis to anywhere- spread in lymphatics
— is most common canine oral malignancy
oral melanoma
40% of tumors in mouth
less common in cats
anywhere is mouth, tissue destruction, rapid metastasis to anywhere in the body
Malignant Melanoma
oral squamous cell carcinoma is found most commonly in
cats and dogs» horses and cattle
older animals
oral squamous Cell Carcinoma in cats is found —
Sublingual mucosa > gingiva
oral squamous Cell Carcinoma in dogs is found —
unilateral tonsil and gingiva
oral squamous Cell Carcinoma in horse and cattle is found in —
tongue and oropharynx
oral squamous Cell Carcinoma is benign or malignant
malignant
poor prognosis
locally invasive and aggressive metastasis to regional lymph nodes
malignant cat neoplasm
oral squamous Cell Carcinoma
oral squamous Cell Carcinoma looks
large ulcerated masses
extensive surface necrosis & ulceration
highly infiltrative and destroy local tissue and bone
Firm masses from desmoplasia
desmoplasia
Causing or forming adhesions or fibrous connective tissue within a tumor.
histo of oral squamous cell carcinoma
Exophytic or endophytic
Cords & nests of atypical
squamous epithelium → desmosomes, keratinization→ “keratin pearls”
High mitotic index
2˚ Ulcers, inflammation
Desmoplasia→ firm!
— can be Solid tumors (masses) & diffuse infiltrative forms in the GI
Alimentary Lymphoma
Lymphosarcoma
cat Alimentary Lymphoma/Lymphosarcoma cause —
Vomiting, diarrhea, or constipation
infiltrative disease causes exudative diarrhea
prognosis of cat with Lymphosarcoma
Poor prognosis (75% 2mo mortality w/o treatment)
cat with Lymphosarcoma is caused by — or —
FeLV
sponatneous
can be seen in all ages of cats
affects the Jejunum, ileum +/- liver & kidney
— is the most common GI neoplasm in cows
abomasal LSA (lymphocarcoma)
cat intestine presents with Vomiting, diarrhea, or constipation
solid form Alimentary Lymphoma/Lymphosarcoma
cat
diffuse form of Alimentary Lymphoma/Lymphosarcoma
looks like johne’s disease in cow
Most common GI neoplasia in the dog (seen in all
species); 2nd most common GI neoplasia in the cat
Adenocarcinoma
cat
Alimentary Lymphoma/Lymphosarcoma (LSA)
adenocarcinoma cause — neoplasms with — that form white — lesions with stenosis — lesions
invasive
desmoplasia
firm
napkin-ring
adenocarcinoma will —
metastasis
carcinomatosis
clinical signs of adenocarcinoma in the stomach
gastric ulcer, vomiting, anorexia
clinical signs of adenocarcinoma in the colon
constipation pain & straining on defecation
(tenesmus), blood in feces (hematochezia)
prognosis of adenocarcinomas
poor- local invasion and metastasis
very common in Dogs
dog
Intestinal adenocarcinoma with desmoplasia → Stenosis (“NAPKIN RING” lesion)
carcinomatosis
— Associated with gastric (pyloric) & proximal duodenal ulcers. Due to increased circulating histamine produced by tumor
mast cell tumors
— is a combo of hypersensitivity and immune mediated disease and will have what cell types
Inflammatory Bowel Disease
will have Eosinophilic +/or lymphoplasmacytic
inflammation
IBD will infiltrate the — and — and cause erosion and ulcers leading to —
lamina propria
submucosa
crypt atrophy and fibrosis
chronic inflammation will cause dysmotility and cause smooth muscle
hypertrophy
some things that cause hypersensitivity reaction of IBD are
Environmental or food allergy
Dysbiosis
Parasites
+/- “Pre-lymphoma” (esp lymphoplasmacytic form
prognosis of IBD
Chronic, progressive, can respond to immunomodulation
Cause of chronic colic- sm mm hypertrophy→ obstruction
feline
FE Eosinophilic Enteritis → Smooth Muscle Hypertrophy
caused by IBD
(+/- viral etiology, benign, proliferative in mouth of young animals
papilloma
Adenocarcinoma (—)- invasive→ 2° gastric ulcers & metastasis
dogs
Squamous cell carcinoma (—) invasive +/- metastasis
horses
Lymphoma (BV, FE): —cause in cattle (BLV) & cats (—)
lentiviral
FeLV
IBD (FE, K9, EQ)→ progressive→ dysmotility & smooth —
muscle hypertrophy
Lymphoma (FE, K9, EQ, PO)→ — forms→ metastatic
nodular & diffuse
Mast cell tumor (K9, FE)- invasive, metastatic→ 2° —
gastric ulcers
—: (benign proliferative) ZOONOTIC!!!
Papular stomatitis & ORF