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22 fall: path > Test 2: 8 cancer > Flashcards

Test 2: 8 cancer Flashcards

1
Q

— is common in cats and huskys and akitas

A

Eosinophilic Granulomas

Non-Neoplastic, Proliferative & Inflammatory Lesions

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2
Q

Eosinophilic Granulomas look like

A

Ulcerated Solitary Masses & Plaques

found in the mouth

Eosinophilic granulomatous inflammation with
flame figures

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3
Q
A

Eosinophilic Granulomas

flame figures
inflammatory lesion in cats and arctic dog breeds

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4
Q

Chronic Lymphocytic Plasmacytic-
Gingivitis-Stomatitis (LPGS) Complex occurs in

A

cats

88% have feline herpes or feline calicivirus

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5
Q

what does Chronic Lymphocytic Plasmacytic-
Gingivitis-Stomatitis (LPGS) Complex look like

A

Gingiva & buccal mucosa (Caudal pharynx, tonsil region!)
* Raised, thickened, hyperemic plaques → erosion and ulcers

associated with Feline Odontoclastic Resorptive Lesions (FORL)

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6
Q

LPGS is associated with

A

Feline Odontoclastic Resorptive Lesions (FORL)

most cases also have feline herpes and feline calici

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7
Q

LPGS cause severe submucosal —-

A

lymphoplasmacytic
infiltrates that lead to erosion and ulcers

may be hypersensitivity rxn or immune mediated

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8
Q

cat

A

Chronic Lymphocytic Plasmacytic-
Gingivitis-Stomatitis (LPGS)

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9
Q
A

Papular Stomatitis

ORF in camelids

caused by parapoxviruses

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10
Q

Papular Stomatitis is caused by

A

Parapoxviruses- Zoonontic

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11
Q

pathogenesis of papular stomatitis (ORF)

A
  • Epithelial cell infection → Virus-induced hyperplasia &
    dysplasia → Epithelial degeneration → Inflammation- expands
    submucosa / dermis too! → Pustules, ulcers & crusts
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12
Q
A

bovine viral papular stomatitis

caused by parapoxvirus

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13
Q

— can spontaneously regress

A

papillomas

stimulate cytotoxic T cell response

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14
Q

papilloma lesion has —stratified squamous
epithelium (+/- viral inclusions)

A

Hyperplastic & dysplastic

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15
Q

papillomas are caused by

A

virus
congenital
idiopathic

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16
Q

papillomas look

A

big, cauliflower masses on the mouth or lips

multiple or solitary

Exophytic, verrucous

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17
Q

papillomas are benign or metastatic

A

benign neoplasms

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18
Q
A

Fibrogingival Hyperplasia (FGH)

benign- found in older boxers

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19
Q

papillomas are common in — animals

A

younger

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20
Q

— benign neoplasm is Associated with chronic
gingivitis/periodontal dz!

A

Fibrogingival Hyperplasia (FGH)

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21
Q

differential for Fibrogingival Hyperplasia (FGH)

A

Peripheral
Odontogenic Fibroma (POF)

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22
Q

Fibrogingival Hyperplasia (FGH) looks

A

firm smooth nodules

older dogs

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23
Q

FGH cause — histo

A

Hyperplastic mucosa Hyperplastic

Proliferative fibrovascular
Mucosa tissue

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24
Q

Peripheral Odontogenic Fibroma (POF) is a neoplasm of

A

the periodontal ligament

older dogs

previously called epulis/epulides

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25
Q

Peripheral Odontogenic Fibroma (POF) are metastatic or benign

A

benign neoplasm of the periodontal ligament

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26
Q

what do Peripheral Odontogenic Fibroma (POF) look like

A

benign proliferative mass near teeth

large and firm

pedunculated or sessile

looks similar to FGH or acanthomatous ameloblastoma

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27
Q

histo of Peripheral Odontogenic Fibroma (POFs)

A

Peripheral Odontogenic Fibroma

Periodontal ligament-like stroma

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28
Q

Acanthomatous Ameloblastoma (AA) has —, but post surgical recurrence is common

A

no metastasis

aggressive neoplasm

infiltrates bone- difficult to get good margin

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29
Q

Acanthomatous Ameloblastoma (AA) grossly resembles

A

benign
fibrogingival hyperplasia or POF

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30
Q

histro of Acanthomatous Ameloblastoma (AA)

A

neoplasm driven by odontogenic epithelium (ameloblasts) →opposite of POFs

cords and solid sheets of neoplastic ameloblasts(cells which secrete the enamel proteins) +/- osseous & dentinous elements

31
Q
A

Acanthomatous Ameloblastoma (AA)

could be POF- need histo to determine

32
Q

Oral Melanoma are benign or malignant?

A

malignant- very poor prognosis

rapid metastasis to anywhere- spread in lymphatics

33
Q

— is most common canine oral malignancy

A

oral melanoma

40% of tumors in mouth
less common in cats

anywhere is mouth, tissue destruction, rapid metastasis to anywhere in the body

34
Q
A

Malignant Melanoma

35
Q

oral squamous cell carcinoma is found most commonly in

A

cats and dogs» horses and cattle

older animals

36
Q

oral squamous Cell Carcinoma in cats is found —

A

Sublingual mucosa > gingiva

37
Q

oral squamous Cell Carcinoma in dogs is found —

A

unilateral tonsil and gingiva

38
Q

oral squamous Cell Carcinoma in horse and cattle is found in —

A

tongue and oropharynx

39
Q

oral squamous Cell Carcinoma is benign or malignant

A

malignant

poor prognosis

locally invasive and aggressive metastasis to regional lymph nodes

40
Q

malignant cat neoplasm

A

oral squamous Cell Carcinoma

41
Q

oral squamous Cell Carcinoma looks

A

large ulcerated masses

extensive surface necrosis & ulceration

highly infiltrative and destroy local tissue and bone

Firm masses from desmoplasia

42
Q

desmoplasia

A

Causing or forming adhesions or fibrous connective tissue within a tumor.

43
Q

histo of oral squamous cell carcinoma

A

Exophytic or endophytic

Cords & nests of atypical
squamous epithelium → desmosomes, keratinization→ “keratin pearls”

High mitotic index

2˚ Ulcers, inflammation

Desmoplasia→ firm!

44
Q

— can be Solid tumors (masses) & diffuse infiltrative forms in the GI

A

Alimentary Lymphoma

Lymphosarcoma

45
Q

cat Alimentary Lymphoma/Lymphosarcoma cause —

A

Vomiting, diarrhea, or constipation

infiltrative disease causes exudative diarrhea

46
Q

prognosis of cat with Lymphosarcoma

A

Poor prognosis (75% 2mo mortality w/o treatment)

47
Q

cat with Lymphosarcoma is caused by — or —

A

FeLV
sponatneous

can be seen in all ages of cats
affects the Jejunum, ileum +/- liver & kidney

48
Q

— is the most common GI neoplasm in cows

A

abomasal LSA (lymphocarcoma)

49
Q

cat intestine presents with Vomiting, diarrhea, or constipation

A

solid form Alimentary Lymphoma/Lymphosarcoma

50
Q

cat

A

diffuse form of Alimentary Lymphoma/Lymphosarcoma

looks like johne’s disease in cow

51
Q

Most common GI neoplasia in the dog (seen in all
species); 2nd most common GI neoplasia in the cat

A

Adenocarcinoma

52
Q

cat

A

Alimentary Lymphoma/Lymphosarcoma (LSA)

53
Q

adenocarcinoma cause — neoplasms with — that form white — lesions with stenosis — lesions

A

invasive
desmoplasia
firm
napkin-ring

54
Q

adenocarcinoma will —

A

metastasis

carcinomatosis

55
Q

clinical signs of adenocarcinoma in the stomach

A

gastric ulcer, vomiting, anorexia

56
Q

clinical signs of adenocarcinoma in the colon

A

constipation pain & straining on defecation
(tenesmus), blood in feces (hematochezia)

57
Q

prognosis of adenocarcinomas

A

poor- local invasion and metastasis

very common in Dogs

58
Q

dog

A

Intestinal adenocarcinoma with desmoplasia → Stenosis (“NAPKIN RING” lesion)

59
Q
A

carcinomatosis

60
Q

— Associated with gastric (pyloric) & proximal duodenal ulcers. Due to increased circulating histamine produced by tumor

A

mast cell tumors

61
Q

— is a combo of hypersensitivity and immune mediated disease and will have what cell types

A

Inflammatory Bowel Disease

will have Eosinophilic +/or lymphoplasmacytic
inflammation

62
Q

IBD will infiltrate the — and — and cause erosion and ulcers leading to —

A

lamina propria
submucosa
crypt atrophy and fibrosis

63
Q

chronic inflammation will cause dysmotility and cause smooth muscle

A

hypertrophy

64
Q

some things that cause hypersensitivity reaction of IBD are

A

Environmental or food allergy
Dysbiosis
Parasites
+/- “Pre-lymphoma” (esp lymphoplasmacytic form

65
Q

prognosis of IBD

A

Chronic, progressive, can respond to immunomodulation

Cause of chronic colic- sm mm hypertrophy→ obstruction

66
Q

feline

A

FE Eosinophilic Enteritis → Smooth Muscle Hypertrophy

caused by IBD

67
Q

(+/- viral etiology, benign, proliferative in mouth of young animals

A

papilloma

68
Q

Adenocarcinoma (—)- invasive→ 2° gastric ulcers & metastasis

A

dogs

69
Q

Squamous cell carcinoma (—) invasive +/- metastasis

A

horses

70
Q

Lymphoma (BV, FE): —cause in cattle (BLV) & cats (—)

A

lentiviral

FeLV

71
Q

IBD (FE, K9, EQ)→ progressive→ dysmotility & smooth —

A

muscle hypertrophy

72
Q

Lymphoma (FE, K9, EQ, PO)→ — forms→ metastatic

A

nodular & diffuse

73
Q

Mast cell tumor (K9, FE)- invasive, metastatic→ 2° —

A

gastric ulcers

74
Q

—: (benign proliferative) ZOONOTIC!!!

A

Papular stomatitis & ORF

22 fall: path (46 decks)

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