Test 2: 15 pancreas

Question 1

micro anatomy of the exocrine pancreas

Answer 1

acinar cells drain into ducts

Question 2

Answer 2

Pacinian corpuscles

pressure and vibration

Question 3

function of the exocrine pancreas

Answer 3

bicarbonate production
enzyme secretion

Question 4

during pancreatic exocrine atrophy — cells will shrink and — granules are reduced or absent

Answer 4

acinar
zymogen

Question 5

Answer 5

severe acinar atrophy

pancreas has disappeared!

Question 6

two causes of pancreatic necrosis

Answer 6

direct acinar injury
duct obstruction - rare

Question 7

what happen during pancreatic necrosis

Answer 7

there is inhibiton of enzyme secretion and the enzyme build up inside the acinar cells cytoplasm

cause colocalizaion of lysosomes and zymogen granules early while still in pancreas (early activation)

trypsin will start breaking down pancreas instead of food in the GI tract

Question 8

explain

Answer 8

pancreas cell will normally release lysosmal granules and trypsinogen into duct where it is activated into trypsin and breaksdown food in the GI tract

if something blocks excretion from the acinar cell, activation will happen inside the cell and start to break itself down

Question 9

autodigestion of the pancreas will cause

Answer 9

◦ Fat necrosis + calcium = saponification of fat

◦ Necrosis of blood vessels = thrombosis, edema,
hemorrhage ➔ more necrosis

◦ Inflammation ➔ more necrosis due to neutrophil
enzymes

Fibrosis

Question 10

systemic effects of pancreatic necrosis

Answer 10

Shock

Disseminated intravascular
coagulation (DIC)

Systemic inflammatory reaction syndrome (SIRS)

Death

Question 11

gross lesion of pancreas necrosis will show

Answer 11

Swollen firm hemorrhagic and / or necrotic pancreas

Peripancreatic fat necrosis (saponification)

Thrombi

peritoneal effusion with fat droplets

Peritonitis with adhesions

Question 12

Answer 12

pancreas necrosis

areas of saponification

Question 13

Answer 13

pancreas necrosis

areas of saponification

Question 14

acute inflammation in the pancreas is in response to —

Answer 14

necrosis

or ascending infection

Question 15

fibrosis may be associated with exocrine pancreatic insufficiency if associated with —

Answer 15

severe atrophy

Question 16

Exocrine Pancreatic Atrophy (Juvenile Pancreatic Atrophy) occurs in — animals

Answer 16

dogs- german shepherd

EPI- exocrine pancreatic insufficiency

Question 17

clinical signs of Exocrine Pancreatic Atrophy (Juvenile Pancreatic Atrophy)

Answer 17

maldigestion ((chunks of undigested meat and lipids) diarrhea/steatorrhea), weight loss, poor coat,
ravenous appetite

Question 18

how to treat exocrine pancreatic insufficieny in german Shepherd

Answer 18

give enzymes- freeze dried pancreas

Question 19

feline triaditis includes

Answer 19

cholangitis
pancreatitis
enteritis

Question 20

feline triaditis will cause

Answer 20

rope/thickened GI- IBD
nodular/ fibrosis pancreas
discolored liver

Question 21

Nodular acinar or ductular hyperplasia of the pancreas are —

Answer 21

incidental finding

Question 22

is it common to have adenoma of the exocrine pancreas?

Answer 22

rare

Question 23

carinomas and adenocarcinomas of the pancreas will metastasize through the —

Answer 23

lymph nodes and liver

carcinomatosis

Question 24

Answer 24

nodular hyperplasia of pancreas

incidental findin

Question 25

common secondary site of pancreatic carcinoma

Answer 25

liver