Test 2 14 liver 3 Flashcards
liver trematode
Hepatic Tremadoiasis- flukes
Fasciola Hepatica-Bovine
cat
Hepatic Trematodiasis Opisthorchis felineus-Feline
horse
Serum hepatitis in horses Theiler’s Disease
associated with administration of xenobiotics, vaccines, idiopathic, Equine Parvovirus Hepatitis
Serum hepatitis in horses Theiler’s Disease causes
Acute massive necrotizing hepatitis of the liver
dish rag liver
chronic hepatitis can be associated with — accumulation and can lead to —
copper
cirrhosis
— is when dog forms many shunts due to portal hypotension and hypoalbuminemia
lobular dissecting hepatitis
— is rare and causes Mixed inflammation with fibroplasia throughout sinusoids-separates individual hepatocytes
Lobular Dissecting Hepatitis
how do cats get chronic cholangitis
ascending infection up bile duct or idiopathic or immune mediated
two types of cholangitis
suppurative- secondary to bacterial infection
lymphocytic
3 forms of cholangitis in a cat
Proliferative Cholangitis - fluke infestation
suppurative- secondary to bacterial infection
lymphocytic
predictable vs idiosyncratic
Predictable (dose dependent) ex. CCl4
Idiosyncratic (non-dose dependent) ex. phenobarbital (individual effected differently then other)
Direct vs. indirect toxins
Direct toxins may affect the periportal region predominately
Indirect toxins may affect a given region of the liver where it is metabolized- centrilobular region predominately as they are metabolized to a toxic intermediate (higher concentration of mixed function oxidases
and conjugation in this region). But it depends on where the metabolic
pathway is located- compare Allyl alcohol v. CCl4 below.
— toxins are toxic as they are ingested
direct
cyanide
— toxins are not toxic when eaten but when broken down becomes toxic
indirect
toxic liver injury causes
asymptomatic → patterned necrosis
pyrrolizidine alkaloid toxicosis causes
Necrosis
Dissociation
Biliary Proliferation
Megalocytosis
Fibrosis
Cirrhosis associated with phenobarbital in dogs
cat
Necrosis and lipidosis associated with benzodiazepines in cats