Test 2 14 liver 3 Flashcards
liver trematode
Hepatic Tremadoiasis- flukes
Fasciola Hepatica-Bovine
cat
Hepatic Trematodiasis Opisthorchis felineus-Feline
horse
Serum hepatitis in horses Theiler’s Disease
associated with administration of xenobiotics, vaccines, idiopathic, Equine Parvovirus Hepatitis
Serum hepatitis in horses Theiler’s Disease causes
Acute massive necrotizing hepatitis of the liver
dish rag liver
chronic hepatitis can be associated with — accumulation and can lead to —
copper
cirrhosis
— is when dog forms many shunts due to portal hypotension and hypoalbuminemia
lobular dissecting hepatitis
— is rare and causes Mixed inflammation with fibroplasia throughout sinusoids-separates individual hepatocytes
Lobular Dissecting Hepatitis
how do cats get chronic cholangitis
ascending infection up bile duct or idiopathic or immune mediated
two types of cholangitis
suppurative- secondary to bacterial infection
lymphocytic
3 forms of cholangitis in a cat
Proliferative Cholangitis - fluke infestation
suppurative- secondary to bacterial infection
lymphocytic
predictable vs idiosyncratic
Predictable (dose dependent) ex. CCl4
Idiosyncratic (non-dose dependent) ex. phenobarbital (individual effected differently then other)
Direct vs. indirect toxins
Direct toxins may affect the periportal region predominately
Indirect toxins may affect a given region of the liver where it is metabolized- centrilobular region predominately as they are metabolized to a toxic intermediate (higher concentration of mixed function oxidases
and conjugation in this region). But it depends on where the metabolic
pathway is located- compare Allyl alcohol v. CCl4 below.
— toxins are toxic as they are ingested
direct
cyanide
— toxins are not toxic when eaten but when broken down becomes toxic
indirect
toxic liver injury causes
asymptomatic → patterned necrosis
pyrrolizidine alkaloid toxicosis causes
Necrosis
Dissociation
Biliary Proliferation
Megalocytosis
Fibrosis
Cirrhosis associated with phenobarbital in dogs
cat
Necrosis and lipidosis associated with benzodiazepines in cats
scute copper toxicity is sheep is caused by
stress
leads to copper buildup in liver then kidney
dies from kidney disease
Hepatosis dietetica is because of — deficiency
vitamin E and Se
same with mulberry heart disease
macronodular cirrhosis
small liver, big nodules
micronodular cirrhosis
small to normal sized liver
small nodules
what kind of cirrhosis
macronodular
Hepatocutaneous Syndrome
Superficial Necrolytic Dermatitis presents with what liver disease
Hepatocutaneous Syndrome
hyperplastic lesions in the liver are usually —
incidental
nodular hyperplasia
usually incidental
how to tell nodular hyperplasia from neoplastic
hyperplasia still has portal triads
Hepatocutaneous Syndrome
with lipidosis
Cholangiocellular (biliary) cystadenoma - dog
Cholangiocellular (bile duct) cystadenoma - cat
Gall bladder adenoma
Hepatocellular carcinoma -dog
Cholangiocellular (bile duct) carcinoma
with desmoplasia and umbilification
metastatic
cholangiocellular carcinoma or hepatocellular carcinoma is metastatic
cholangiocellular carcinoma
poor prognosis- cats > dogs
— cause diffuse hepato megaly
hymphoma
nodular lymphoma - soft white tane
lymphoma are what texture and color
soft, white and tan
vs hepatocellular carcinoma which are firm
— can look like nodular lymphoma in the liver
Histiocytic sarcoma-
one of the most common tumors in the liver, can also be found in the spleen
hemangiosarcoma
multifocal flat red spots
benign in gallbladder
cystic mucosal hyperplasia in dog
billary mucocele
unknown cause
kiwi fruit gallbladder
billary mucocele
gall bladder stones
choleliths
what kind of jaundice
post hepatic
caused by bile duct obstruction
