some stuff that is apparently MSK Flashcards
Fibromyalgia, sclerosis, and vasculitis.
risk factors for fibromyalgia
female (6:1) middle age low household income divorce low educational status
signs of fibromyalgia
low mood
poor concentration
symptoms of fibromyalgia
chronic fatigue
widespread pain
paraesthesia
which diseases is fibromyalgia associated with?
Chronic fatigue syndrome
IBS
SLE
diagnosis of fibromyalgia
clinical diagnosis
diagnosis of exclusion
treatment of fibromyalgia
long term graded exercise programme
low dose amitriptyline
SSRIs
CBT
risk factors for systemic sclerosis
genetic/family history infectious agents chemicals drugs radiation therapy physical trauma vitamin D deficiency
name some infections that can be a risk factor for systemic sclerosis
cytomegalovirus parvovirus B19 H. pylori hepatitis B EBV
pathology of systemic sclerosis
excessive collagen production
vascular damage
immune activation via autoantibody production and cell-mediated autoimmune mechanisms
which antibodies are implicated in systemic sclerosis?
anti-topoisomerase 1
anti-centromere antibody
anti-RNA polymerase III antibody
signs of LcSSC (limited cutaneous systemic sclerosis)
sclerodactyly long history of Raynaud's less skin involvement slow onset and progression symptoms may be unnoticed until internal complications occur
signs of dcSSc (diffuse cutaneous systemic sclerosis)
proximal scleroderma and trunk involvement rapid onset skin thickening Raynaud's phenomenon symptoms worse in first 3-5 years internal organ involvement
complications of systemic sclerosis
malignancy Sjogren's depression osteoporosis (due to reduced blood flow) hypothyroidism calcium deposits in fingers (due to scleroderma)
diagnosis of systemic sclerosis
bloods - CRP, ESR, FBC, renal function
autoantibodies
imaging
urinalysis (proteins)
treatment of systemic sclerosis
physiotherapy
immunotherapy
symptomatic relief
