respiratory disease - COPD, asthma, and lung cancer Flashcards
Risk factors, pathology, clinical signs, complications, diagnosis, and treatment for various respiratory conditions.
COPD includes
chronic bronchitis
emphysema
asthma
bronchiectasis
COPD definition
airflow obstruction caused by small airways disease and parenchymal destruction
emphysema risk factors
alpha-1-antitrypsin deficiency
coal dust
cadmium toxicity
COPD risk factors
middle aged men cigarette smoke occupational dust and chemicals pollution low socio-economic status childhood infections genetics
clinical definition of COPD
cough and sputum for 3 months in 2 consecutive years
pathology of COPD
mucous hypersecretion with bronchial mucous gland hypertrophy
loss of ciliated cells, squamous metaplasia
respiratory bronchiolitis
later stages of COPD
hypercapnia, hyperaemia, cyanosis
carcinogenic - dysplastic metaplastic squamous epithelium
clinical signs of COPD
cough dyspnoea/tachypnoea shortness of breath hyperinflation use of accessory muscles on inhalation low PaO2 high PaCO2 (low alveolar ventilation)
why do patients with COPD get pulmonary hypertension?
obliteration and vasoconstriction
pink puffer
weight loss
breathless
emphysematous
maintained pO2
blue bloater
cough
phlegm
cor pulmonale
respiratory failure (type 2)
complications of COPD
cor pulmonale - pulmonary hypertension and fluid overload
COPD spirometry
always abnormal
diagnosis of COPD
FEV1 <80% of predicted
FEV1:FVC ratio <70% predicted
staging of COPD
- FEV1 >80%
- FEV1 50-79%
- FEV1 30-49%
- FEV1 <30%
treatment for patients with upper lobe predominant emphysema
lung reduction surgery
treatment for mild COPD (stage 1)
ipratropium bromide
treatment for moderate COPD (stage 2)
tiotropium
treatment for severe COPD (stage 3)
glucocorticosteroid (beclamethasone diproprionate)
treatment for very severe COPD (stage 4)
home O2
first line treatments for COPD
stop smoking
exercise
ß2 agonists