some random GI stuff Flashcards
risk factors for Coeliac disease
Irish
female
HLA DQ2 gene
pathology of Coeliac disease
reaction to gliadin - T cell mediated
villous atrophy and malabsorption of bile acids and crypt hyperplasia
signs of Coeliac disease
diarrhoea that smells offensive bloating abdominal pain nausea and vomiting aphthous ulcers weight loss angular stomatitis fatigue
complications of Coeliac disease
osteoporosis malignancies (if pt does not adhere to diet)
diagnosis of coeliac disease
jejunal and duodenal biopsies
serology - tissue transglutaminase and anti-endomysial antibodies
gastroscopy
treatment of coeliac disease
gluten free diet
risk factors for oesophageal reflux
hiatus hernia
gastric surgery
increased abdominal pressure
symptoms of oesophageal reflux
heartburn (acid reflux)
complications of oesophageal reflux
Barrett’s oesophagus
carcinomas
hyperplasia
metaplasia
diagnosis of oesophageal reflux
endoscopy
GI bleeding
pH monitoring
treatment of oesophageal reflux
antacids (magnesium trisilicate mixture) PPIs (omeprazole) H2RA (ranitidine) weight loss meal planning dietary restraint
risk factors for peptic ulcers
inappropriate NSAID use
peptic ulcers
pathology of peptic ulcers
ulceration in gastric mucosa, usually due to a pH decrease
signs of peptic ulcers
haematemesis
melaena (dark, sticky faeces)
weight loss
epigastric pain
complications of peptic ulcers
peritonitis if perforation
pancreatitis
haemorrhage
diagnosis of peptic ulcers
endoscopy
H.pylori test
treatment for peptic ulcers
triple therapy: PPI, clarithromycin, amoxiclav
stop NSAIDs
stop smoking
what normally protects gastric cells from acid?
mucin
mesenteric ischaemia risk factors
chronic renal failure past MI AF heart failure thrombophilia
pathology of mesenteric ischaemia
restriction of blood flow to mesentery (acute or chronic)