alcoholic liver disease and cirrhosis Flashcards
risk factors for alcoholic liver disease
long term heavy alcohol consumption
pathology of alcoholic liver disease
metabolism of alcohol –> increase in hepatic fatty acids –> accumulation –> steatosis –> necrosis –> inflammation –> cirrhosis
histological signs of alcoholic liver disease
Mallory bodies
giant mitochondria
signs of mid stage alcoholic liver disease
tachycardia febrile tachypnoea anorexia malaise
signs of late stage alcoholic liver disease
hepatomegaly peripheral oedema ascites jaundices encephalopathy coagulopathy
early stage symptoms of alcoholic liver disease
nausea
vomiting
diarrhoea
complications of alcoholic liver disease
spontaneous bacterial peritonitis
liver carcinoma
what is a sign that a patient does not have alcoholic liver disease?
ALT increases more than AST
–> think of an alternative diagnosis
diagnosis of alcoholic liver disease
AST:ALT >2 bilirubin up albumin down WCC up macrocytic anaemia PTT up
treatment for alcoholic fatty liver
abstinence
treatment for alcoholic hepatitis
abstinence
withdrawal supplements
steroids
risk factors for cirrhosis
alcoholism
poor diet
IV drug use
causes of cirrhosis
hepatitis B and C virus alcohol autoimmune liver disease Wilson's disease recurrent biliary obstruction haemachromatosis
pathology of cirrhosis
fibrosis
modular regeneration (micro or macronodular)
loss of organisation
signs of cirrhosis
hepatomegaly jaundice spider Naevi ascites clubbing leukonychia Terry's nail palmar erythema Dupuytren's contracture xantelasma gynaecomastia loss of body hair atrophic testes
