REPRO 5 Flashcards
plasma volume increases by how in pregnancy leading to what
50%
anaemia
BP does what
GFR
CO
goes down in second trim
up leading to decreased CR and UR
increase - systolic ejection murmur
ACEI/ARBs
renal hyperplasia
androgens
civilisation of females
anti epileptics
cardiac, facial , NT
cytotoxic
multiple defects, abortion
lithium
CDV
methotrexate
skeletal
retinoids
ear, CDV, skeletal
warfarin
limb and facial
tetracycline
stains bone and teeth of kids
avoid in children under 8
phenytoin
cleft lip and palate
stillbetrol
vaginal adenocarcinoma in girls
urological malignancy in boys
valproate
NT
warfarin around labour
bleed
opiates around labour
resp depression - prem closure of DA
SSRI opiates
NAS
phenybarbitone in breast feeding
suckling difficulties
amiodaron in breast feeding
neonatal hypothyroidism
cytotoxic in breast feeding
BM suppression
BZDs in breast feeding
drowsiness
bromocriptine in breast feeding
surpasses lactation
rx for N/V
cyclizine
rx for UTI
nitro and ceflaxine
trim in 3rd trim
pain rx
heart burn
paracetamol
antacids
epilepsy in pregnancy why does the seizure rate go up
non compliance
changes in plasma concentration - committing and increased clearance
what does frequent seizures lead to
low IQ, brady, IUD, maternal death
treatment of epilepsy
5mg FA 3m prior to conception and throughout
vit K 34-36w 20mg PO if taking hepatic enzyme inducers
risk of child developing epilepsy
5% if mum/dad
15% if both mum and dad
10% if sibling and mum/dad
anti epileptics SE
NTD, orofacial, cardiac,
fetal anticonvulsant syndrome: dysmorphic features, hypo plastic nails and distal digits
stopping phenobarbital
neonatal withdrawal convulsions
scans during epilepsy
detailed metal scan at 18-20w
detailed cardio scan at 22w
cs when in epilepsy
recurrent gen seizures in late pregnancy or labour
post partum in epileptic mothers
neonates IM 1mg vit k
pre existing DM leads to what in pregnancy
poorer control
renal and eye deterioration
what DM drug is not safe in pregnancy
SUs
GDM
fasting glucose >=5.6 2hours >=7.8
target for fasting
1h after meal 2h
- 3
- 8
- 4
retinal screening when
every trim
postnatal follow up of BG
stop treatment and moniter for 24 hours
fetal macrosomia can lead to what
c section when
should dystocia
>4kg
polyhydraminoas risk of what
preterm, malpresentation, cord collapse
polycythaemia risk of what
unexplained stillbirth, thrombotic events, jaundice
neonatal hypoglycaemia risk of what
cerebral palsy
IOL when in pre existing DM
GDM on insulin
37-18w
38w
important to monitor for what in DM
PET
pregnancy has a what fold risk of VTE
10 fold
what is the leading cause of maternal death
VTE
why does pregnancy have a high risk of VTE
increase in factors 7, 8, 10, fibrinogen
decrease in protein S
low risk for VTE treatment
mobilise and keep hydrated
intermediate risk for VTE rx
consider LMHW proph
high risk for VTE rx
LMWH proph
dose of LMWH in pregnancy and for how long
1mg/kg
3m after birth or 6m after beginning of treatment
heparin SE
haemorrhage, h/s, osteopenia, heparin induced thrombocytopenia
warfarin SE
teratogenic, haemorrhage
when should heparin be stopped
planned delivery what
24 before
give proph dose 12h before
hypothyroid rx
increase levothyroxin by 25-50mcg in first trim
hyperthyroid why does it get worse in first trim
because of HCG
risks of hyperthyroid
IUGR, prem, thyroid storm
rx for hyperthyroid
PTU
thyroid and pregnancy monitoring
TFTs every trim
anaemia when to give oral iron at booking
at 28 weeks
<11g/dl
<10.5
