REPRO 3.5 Flashcards
what is endometrial hyperplasia
abnormal endometrial gland proliferation
risk factors for hyperplasia
persistent and unopposed oestrogen stimulation: obesity, tamoxifen, PCOS, exogenous oestrogen
null parity, DM
what decreases the risk for endometrial cancer
COCP
who does endom ca occur in
80% post meno
if younger consider endometriosis/Lynch synd
symptoms of endometrial cancer
macro
micro
abnomalr bleeding.
large uterus/polypoid/grapefruit
most adenocarcinoma and well differentiated
Type 1 what percent
what two types
and what are the risk factors and precursor
80% endometriod mucinous unopposed oestrogen precursor - atypical hyperplasia
good prognosis
endometroid
always low grade
mucinous
endometriod staging
1 5% or solid growth
2 6-50% solid growth
3 >50% solid growth
Type 2 what types
who gets this
RF
what is this not assoc with
serous clear cell elderly post meno mutated TP53. precursor - serous intraepithelial carcinoma unopposed oestrogen
high grade by def
serous and clear cell
staging of endometrial cancer
1A
1B
3A, 3B, 3C, 4
1A <50% OF MYOMETRIUM INVASION 1B >50% 2 cervical stroma 3A serora of uterus /adnexea 3B vaginal/parametrial involvement 3C mets to pelvic +/or paraortic Los 4 bladder/bowel mucosa/distant mets
TVUSS thickness cut offs for biopsy
> 4mm in post meno
>16mm in pre
gold standard ix for endometrial ca
hysterescopy and biopsy
endometrial stromal sarcoma is what
symp
rare, soft, fleshy, usually polypoid masses, high grade
abnormal uterine bleeding, lung/ovarian mets
