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4 MBCHB > NEURO 7 > Flashcards

NEURO 7 Flashcards

1
Q

myotonic dystrophy genetics

symptoms

A

ADom
myotonia, weakens, cataracts, frontal balding, ptosis, cardiac
MULTISYSTEM INVOLVEMENT

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2
Q

rhabdo is what
leads to what
ix
rx

A

breakdown of skillets muscle
AKI, black pee
AKI, increased Cr, decreased Ca, increased Phos
IV fluids

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3
Q

curare does what

A

occupies same position on Acc receptors but doesn’t open ion channel - no muscle contraction - no respiration

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4
Q

MG is what
symptoms
ix

A

post synaptic disease
prox limb weakness worse throughout day, swallowing, eyes
AcH antibodies, anti muscle specific tyrosine kinase ABs
CT - thorax for thymoma, CK is normal

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5
Q

treatment of MG acute and non acute

A

acute plasmapheresis/immunoglobulin
pyridostigmine, pred and aza
thyrectomy

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6
Q

botulism is what
who
symptoms

A

pre synaptic. IVDU. black tar heroin

rapid onset weakness without sensory loss

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7
Q

LE syn is what
related to what
symptoms
rx

A

pre synaptic. ABs to calcium - less vesicle release
SCLC
limb girdle weakness - lower limbs first - muscles get better throughout the day
immunosuppression

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8
Q

migraine with aura or without aura is more common

A

without

only 15-33 with aura

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9
Q

migraine criteria how many attacks
lasting how long
2 of what:
1 of what:

A

at least 5 lasting 4-72 hours
2 of: malaise, unilateral, throbbing pain. worse on movement
1 of: autonomic features photophobia/phonophobia/nausea or vom

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10
Q

what are the different types of aura and which is the commonest one

A

visual, sensory, motor, language

visual commonest

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11
Q

how long does an aura last and when does it occur in relation to the headache

A

20-60 mins full reversible

headache less than 1h later but can be simultaneously

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12
Q

when should imaging be done in patients who present with migraine

A 
>50 and new onset headache 
known malignancy
immunosuppressed
early morning headache 
exacerbated by valsava
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13
Q

acute management of migraine

A

aspirin 900mg or
ibobrufen 400mg-900mg or
sumatriptan 50-100mg +/- naproxen 500mg

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14
Q

second line management of acute migraines

cautions of this drug

A

metoclopiramide

leads to extra pyramidal side effects

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15
Q

acute migraine with nausea and vomitng

A

metaclopiramide or prochlorperazine

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16
Q

what are triptans contraindicated in

A

ishcaemic heart disease

17
Q

criteria for giving prophylaxis for migraines

how long should the trial of proph be

A

> 3 per month

4m

18
Q

prophylaxis 1.
2.
3.
4.

A

propanolol PO OD or Topirimate 25-100mg
amitriptyline
candesartan
Na Val

19
Q

period migraines

A

frovatriptan/zoimetriptan daily PO

20
Q

pregnancy and migraines 1
2
when can these be given

A

1 paracetamol 1g
2 aspirin 300mg/ibobrufen 400mg
in first/second trimester

21
Q

who do clusters happen in and when

A

M 30-40yo around sleep

22
Q

symptoms of clusters

A

restlessness
severe unilateral headache
1-8 per day

23
Q

how long do clusters last and how long can the interval be between bouts of clusters

A

weeks to months

interval can be up to a year

24
Q

acute treatment of cluster headache

prophylactic treatment

A

high flow oxygen for 20 mins and subcut somatotriptan 6mg. steroids that are decreased in dose over 2w

proph verapamil or pred

25
Q

paroxysmal hemicronia in who

A

elderly 50-60yo women

26
Q

difference between PH and clusters

A

10-30mins and 1-4/day

27
Q

treatment of PH

A

indomethan

28
Q

SUNCT

A 
short lived 15-20s
unilateral 
neuralgia form headache 
conjunctival infections
tearing
29
Q

treatment of SUNCT

A

lamotrigene

gabapentin

30
Q

trigeminal neuralgia in who

triggered by what

A

> 60s W>M

triggered by touch and usually V2/V3

31
Q

ix in TN and why

A

MRI

atypical features, poor response to medical treatment or surgery being considered

32
Q

treatment of TN

A

carbamazapine

gabapentin. phenytoin. baclofen

33
Q

surgical treatment of TN

A

ablation/decompression

34
Q

tension headache features

A

bilatera l tight band of mod-severe intensity around head

can radiate to neck

35
Q

are tension headaches aggravated by exercise

A

no

36
Q

treatment of tension headaches acute and proph

A

aspirin and paracetamol

amitrip

37
Q

what counts as a chronic daily headache

A

headache daily for 15 or over days in a month for 3 months

38
Q

causes of chronic daily headache

A

medication overuse

opiod meds or overusing triptans

4 MBCHB (80 decks)

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