Renal Nephrotic/Nephritic Syndromes

Question 1

Membranous GN
LM =
IF =
EM =

Answer 1

LM: BM spikes on silver stain
IF: granular/linear
EM: sub-EPI-thelial spikes and domes

Question 2

Minimal Change Dz 
LM =
IF =
EM =
other notes =

Answer 2

LM = normal
IF = none
EM = podocyte effacement
other notes = #1 nephrotic syndrome in children up to age 20 (USMLE)

Question 3

Focal segmental
LM =
IF =
EM =
other notes =

Answer 3

LM = focal seg. sclerosing
IF = none
EM = none
other notes = MC nephrotic syndrome in adults. Aids, African Americans, Sickle Cell sz pts, IVDA

Question 4

Nodular Glomerular Sclerosis
LM =
IF =
EM =
other notes =

Answer 4

LM = nodular sclerosis of glomeruli, thick BM
IF = none
EM = none
other notes = history of DM, Kimmelstiel wilson nodules, christmas balls

Question 5

Post strep GN
LM =
IF =
EM =
other notes =

Answer 5

LM = hypercellular PMNs
IF = granular (non linear)
EM = subEPi-thelial, lumpy bumpy
other notes = MCC: group A strep, 95% recovery

Question 6

Goodpasture's
LM =
IF =
EM =
other notes =

Answer 6

LM = hypercellular crescents
IF = smooth linear
EM = none
other notes = hemoptysis, Type II HTN, develop RPGN

Question 7

RPGN 
LM =
IF =
EM =
other notes =

Answer 7

LM = hypercellular crescents
IF = crescents made from IgG/C3
EM = none
other notes = RF in wks/months, wegners/goodpastures

Question 8

IgA Nephropathy
LM =
IF =
EM =
other notes =

Answer 8

LM = hypercellular mesangial prolif
IF = mesangial IgA/C3
EM = none
other notes = hematuria, IgA diseases

Question 9

Membranoproliferative GN
LM =
IF =
EM =
other notes =

Answer 9

LM = Hypercellular tram track BM splitting (silver stain)
IF = none
EM = subENDOthelial deposits
other notes = Mixed nephritic and then nephrotic