Liver Tests Flashcards
LFTs: as the AST/ALT vs True liver function
- Common
- AST/ALT, Alkaline phosphatase (ALP)
- bilirubin
- LDH and GGT
- True liver tests are:
- PT/INR
- Albumin
- Cholesterol
AST: ALT - ALT predominant
- Chronic viral hepatitis B, C, D
- Acute viral heptatitis A-E, CMV, EBV
- Steatosis
- Medications/toxins
- Hemochromotisis
- Wilson’s dx
- Alpha 1 antitrypsin deficiency
- Glycogenic hepatopathy
- celiac dx
AST: ALT AST predominant
- Alcohol-related liver injury
- Cirrhosis
Alkaline phosphatase increased
- cholestasis (biliary obstruction)
- infiltrative dis.
- bone disease
gamma glutamyl transpeptidiease
increased in various liver and bilitary disease
NOT elevated in bone related diseases
associated with alcohol use
alpha fetoprotein
increased in hepatocellular carcinoma
Unconjugated hyperbilirubinemia
- hemolytic
- physiologic (newborns)
- Crigler Najjar
- Gilbert yndrome
conjugated (direct) hyperbilirubinemia
- biliary tract obstruction: gallstones, choleangiosarcinoma, pancreatic or liver cancer, liver fluke
-
biliary tract diseases:
- primary sclerosing choleangitis
- primary bilitary cholangitis
- execretion defects: Dubin Johnson syndomre, Rotor syndrome
Mixed (direct and indirect) hyperbilirubinemia
- cirrhosis
- hepatitis
conjugated hyperbilirubinemia, granulomatous bile ducts, anti-mitochondria Abs, xanthomas
primary bilitary cholangitis
SBO
small bowel obstruction
suspected SBO with painless jaundice
pancreatic cancer
yellow tan colonic membranes and watery diarrhea
clostridium difficile
antibodies against DNA (topo I)
scleroderma
anti-centromere antibodies
CREST
