Ovarian Pathology Markers Flashcards
a tumor marker for nonseminomatous testicular cancers
Alpha-fetoprotein (AFP): tumor marker for nonseminomatous testicular
elevated in epithelial ovarian cancers
CA-125: marker that is elevated in epithelial ovarian cancers (serous cystadenocarinoma, mucinous cystadenocarcinomas, etc).
These tumors will not be associated with signs of estrogen excess (ie, endometrial hyperplasia, thickened endometrial stripe etc)
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Alpha-fetoprotein (AFP)
Alpha-fetoprotein (AFP) is a tumor marker for hepatocellular, nonseminomatous testicular, or ovarian cancers.
Schiller-Duval bodies on pathology.
a yolk sac tumor (endodermal sinus tumor): Schiller-Duval (glomeruli-esque) bodies would be present on pathology.
Beta-hCG elevated in
Beta-hCG would be elevated in pregnancy, hydatidiform moles, choriocarcinoma, testicular cancer, or mixed germ cell tumor.
Testosterone is elevated in
Testosterone is elevated in Sertoli-Leydig tumors, which would present with hyperandrogenism (male-pattern baldness, hirsutism, clitoromegaly)
Thyroxine is elevated in
Thyroxine is elevated in struma ovarii and associated with signs of hyperthyroidism (palpitations, weight loss, heat intolerance, etc)
Lactate dehydrogenase
Lactate dehydrogenase is elevated in ovarian dysgerminoma, most common in adolescents. Dysgerminoma is associated with a “fried-egg” appearance on pathology.
Call-Exner bodies
granulosa cell tumor
postmenopausal bleeding, transvaginal endometrial stripe, ovarian mass. laparoscopy: firm, yellow ovarian mass
granulosa cell tumor
patient presents with weight loss, heart palpitations, jitteriness, and sweating. Her mother recently had a thyroidectomy after having similar symptoms. In addition, the patient reports a “pulling” sensation in her groin
struma ovarii with thryoid follicles
