66. Physiologic neonatal jaundice

Question 1

physiologi neonatal jaundice - mechanism

Answer 1

at birth, immature UDP- gluronosyltransferase –> uncojugated hyperbilirubinemia –>d bi jaundice / kernicterus

Question 2

kernicterus ?

Answer 2

biliribin deposition in brain, paarticularly basal ganglia

Question 3

Physiologic neonatal jaundice - course ( time )

Answer 3

occurs after 24 hrs of life and usually resolves without treatment in 1-2 weeks

Question 4

physiologic neonatal jaundice - treatment

Answer 4

phototherapy ( non-UV) isomerizes unconjugated bilirubin to water- soluble form

Question 5

drug that causes kernicterus

Answer 5

sulfonamides

Question 6

• A newborn has a yellowish hue for 12 hours after birth. The doctor says it is a benign condition. What is its molecular basis?

Answer 6

Immature UDP-glucuronosyltransferase in the infant, leading to increased unconjugated bilirubin levels and jaundice

Question 7

• A newborn has a yellow hue for 10 hours after birth. The doctor says it is due to immature UDP-glucuronosyltransferase. Treatment?

Answer 7

Phototherapy, which converts the unconjugated bilirubin into a water-soluble form that can be excreted in urine

Question 8

• A newborn has severe physiologic neonatal jaundice. A doctor wants to start phototherapy to “protect the brain.” What does he mean by this?

Answer 8

Untreated unconjugated hyperbilirubinemia can cause kernicterus (bilirubin deposition in the brain, particularly in the basal ganglia)